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FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons.

Publication ,  Journal Article
Jenkins, SM; Kizhatil, K; Kramarcy, NR; Sen, A; Sealock, R; Bennett, V
Published in: J Cell Sci
November 2001

Phosphorylation of neurofascin, a member of the L1 family of cell adhesion molecules (L1 CAMs), at the conserved FIGQY-tyrosine abolishes the ankyrin-neurofascin interaction. This study provides the first evidence, in Drosophila melanogaster and vertebrates, for the physiological occurrence of FIGQY phosphorylation in L1 family members. FIGQY tyrosine phosphorylation is localized at specialized cell junctions, including paranodes of sciatic nerve, neuromuscular junctions of adult rats and Drosophila embryos, epidermal muscle attachment sites of Drosophila, and adherens junctions of developing epithelial cells of rat and Drosophila. In addition, FIGQY-phosphorylated L1 CAMs are abundantly expressed in regions of neuronal migration and axon extension, including the embryonic cortex, the neonatal cerebellum and the rostral migratory stream, a region of continued neurogenesis and migration throughout adulthood in the rat. Based on our results, physiological FIGQY-tyrosine phosphorylation of the L1 family likely regulates adhesion molecule-ankyrin interactions establishing ankyrin-free and ankyrin-containing microdomains and participates in an ankyrin-independent intracellular signaling pathway at specialized sites of intercellular contact in epithelial and nervous tissue.

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Published In

J Cell Sci

DOI

ISSN

0021-9533

Publication Date

November 2001

Volume

114

Issue

Pt 21

Start / End Page

3823 / 3835

Location

England

Related Subject Headings

  • Tyrosine
  • Tumor Cells, Cultured
  • Rats
  • Phosphorylation
  • Peptides
  • Neurons
  • Neuromuscular Junction
  • Neural Cell Adhesion Molecules
  • Nerve Growth Factors
  • Molecular Sequence Data
 

Citation

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Jenkins, S. M., Kizhatil, K., Kramarcy, N. R., Sen, A., Sealock, R., & Bennett, V. (2001). FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons. J Cell Sci, 114(Pt 21), 3823–3835. https://doi.org/10.1242/jcs.114.21.3823
Jenkins, S. M., K. Kizhatil, N. R. Kramarcy, A. Sen, R. Sealock, and V. Bennett. “FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons.J Cell Sci 114, no. Pt 21 (November 2001): 3823–35. https://doi.org/10.1242/jcs.114.21.3823.
Jenkins SM, Kizhatil K, Kramarcy NR, Sen A, Sealock R, Bennett V. FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons. J Cell Sci. 2001 Nov;114(Pt 21):3823–35.
Jenkins, S. M., et al. “FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons.J Cell Sci, vol. 114, no. Pt 21, Nov. 2001, pp. 3823–35. Pubmed, doi:10.1242/jcs.114.21.3823.
Jenkins SM, Kizhatil K, Kramarcy NR, Sen A, Sealock R, Bennett V. FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons. J Cell Sci. 2001 Nov;114(Pt 21):3823–3835.
Journal cover image

Published In

J Cell Sci

DOI

ISSN

0021-9533

Publication Date

November 2001

Volume

114

Issue

Pt 21

Start / End Page

3823 / 3835

Location

England

Related Subject Headings

  • Tyrosine
  • Tumor Cells, Cultured
  • Rats
  • Phosphorylation
  • Peptides
  • Neurons
  • Neuromuscular Junction
  • Neural Cell Adhesion Molecules
  • Nerve Growth Factors
  • Molecular Sequence Data