The membrane attachment protein for spectrin is associated with band 3 in human erythrocyte membranes.

Journal Article (Journal Article)

Ankyrin, the membrane attachment protein for human erythrocyte spectrin, is tightly linked in a 1:1 molar ratio with band 3 in detergent extracts of spectrin-depleted membranes. Ankyrin-linked band 3, which represents 10--15% of the total band 3, spans the membrane, and is nearly identical to the major band 3 by peptide analysis. Spectrin binds to solubilised ankyrin-linked band 3, but not to free band 3. A portion of band 3 remains firmly associated with detergent-extracted cytoskeletal proteins. It is concluded that a fraction of band 3 is attached to the erythrocyte cytoskeleton through association with ankyrin, which in turn is bound to spectrin.

Full Text

Duke Authors

Cited Authors

  • Bennett, V; Stenbuck, PJ

Published Date

  • August 9, 1979

Published In

Volume / Issue

  • 280 / 5722

Start / End Page

  • 468 - 473

PubMed ID

  • 379653

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/280468a0


  • eng

Conference Location

  • England