Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules.

Journal Article (Journal Article)

Neurofascin, L1, NrCAM, NgCAM, and neuroglian are membrane-spanning cell adhesion molecules with conserved cytoplasmic domains that are believed to play important roles in development of the nervous system. This report presents biochemical evidence that the cytoplasmic domains of these molecules associate directly with ankyrins, a family of spectrin-binding proteins located on the cytoplasmic surface of specialized plasma membrane domains. Rat neurofascin and NrCAM together comprise over 0.5% of the membrane protein in adult brain tissue. Linkage of these ankyrin-binding cell adhesion molecules to spectrin-based structures may provide a major class of membrane-cytoskeletal connections in adult brain as well as earlier stages of development.

Full Text

Duke Authors

Cited Authors

  • Davis, JQ; Bennett, V

Published Date

  • November 4, 1994

Published In

Volume / Issue

  • 269 / 44

Start / End Page

  • 27163 - 27166

PubMed ID

  • 7961622

International Standard Serial Number (ISSN)

  • 0021-9258


  • eng

Conference Location

  • United States