From anemia to cerebellar dysfunction. A review of the ankyrin gene family.
Published
Journal Article (Review)
The focus of this review is on the ankyrin gene family, key elements in the interaction of the spectrin-based membrane skeleton with the plasma membrane in a variety of tissues and multicellular organisms. The structure/function relationships of ankyrin molecules are reviewed, illustrating how these proteins are uniquely suited to serve as adaptors between the membrane skeleton and a number of integral membrane proteins. Advances in the understanding of ankyrin biology in the brain are discussed and used to show how ankyrins may be involved in the establishment and/or maintenance of specialized plasma membrane domains. Finally, recent research in hematological and neurological disorders are reviewed, suggesting that ankyrins have a role in the development of human disease.
Full Text
Duke Authors
Cited Authors
- Lambert, S; Bennett, V
Published Date
- January 15, 1993
Published In
Volume / Issue
- 211 / 1-2
Start / End Page
- 1 - 6
PubMed ID
- 8425519
Pubmed Central ID
- 8425519
International Standard Serial Number (ISSN)
- 0014-2956
Digital Object Identifier (DOI)
- 10.1111/j.1432-1033.1993.tb19863.x
Language
- eng
Conference Location
- England