From anemia to cerebellar dysfunction. A review of the ankyrin gene family.


Journal Article (Review)

The focus of this review is on the ankyrin gene family, key elements in the interaction of the spectrin-based membrane skeleton with the plasma membrane in a variety of tissues and multicellular organisms. The structure/function relationships of ankyrin molecules are reviewed, illustrating how these proteins are uniquely suited to serve as adaptors between the membrane skeleton and a number of integral membrane proteins. Advances in the understanding of ankyrin biology in the brain are discussed and used to show how ankyrins may be involved in the establishment and/or maintenance of specialized plasma membrane domains. Finally, recent research in hematological and neurological disorders are reviewed, suggesting that ankyrins have a role in the development of human disease.

Full Text

Duke Authors

Cited Authors

  • Lambert, S; Bennett, V

Published Date

  • January 15, 1993

Published In

Volume / Issue

  • 211 / 1-2

Start / End Page

  • 1 - 6

PubMed ID

  • 8425519

Pubmed Central ID

  • 8425519

International Standard Serial Number (ISSN)

  • 0014-2956

Digital Object Identifier (DOI)

  • 10.1111/j.1432-1033.1993.tb19863.x


  • eng

Conference Location

  • England