Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10.

Published

Journal Article

The ankyrin3 gene encodes a novel form of ankyrin, AnkyrinG, expressed in multiple tissues but characteristically present at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. We have localized ANK3 to human Chromosome 10q21 by fluorescence in situ hybridization. The position of the murine homologue was determined by intersubspecific backcross analysis, mapping Ank3 to mouse Chromosome 10, between microsatellite marker D10Mit31 and the Bcr gene. This interval is known to comprise a region syntenic to human 10q. The localization of ANK3 is a preliminary step in identifying neurological disorders potentially associated with the gene.

Full Text

Duke Authors

Cited Authors

  • Kapfhamer, D; Miller, DE; Lambert, S; Bennett, V; Glover, TW; Burmeister, M

Published Date

  • May 1995

Published In

Volume / Issue

  • 27 / 1

Start / End Page

  • 189 - 191

PubMed ID

  • 7665168

Pubmed Central ID

  • 7665168

Electronic International Standard Serial Number (EISSN)

  • 1089-8646

International Standard Serial Number (ISSN)

  • 0888-7543

Digital Object Identifier (DOI)

  • 10.1006/geno.1995.1023

Language

  • eng