Proteins closely related to spectrin and ankyrin are general components of cell membranes.

Journal Article

Membrane-associated analogues of erythrocyte spectrin and ankyrin have been detected in nonerythroid cells by crossreaction with antibodies. Brain spectrin and a spectrin-binding domain of brain ankyrin have been purified and demonstrated to have all known functional activities of their erythrocyte counterparts. The nonerythroid forms of spectrin and ankyrin may have functions such as providing support for the lipid bilayer, mediating some types of actin-membrane interactions, and integrating membrane-spanning proteins with cytoplasmic structural proteins.

Full Text

Duke Authors

Cited Authors

  • Bennett, V; Davis, JQ

Published Date

  • 1984

Published In

Volume / Issue

  • 165 /

Start / End Page

  • 457 - 472

PubMed ID

  • 6239291

International Standard Serial Number (ISSN)

  • 0361-7742

Language

  • eng

Conference Location

  • United States