Plasmodium falciparum malaria: band 3 as a possible receptor during invasion of human erythrocytes.

Journal Article (Journal Article)

Human erythrocyte band 3, a major membrane-spanning protein, was purified and incorporated into liposomes. These liposomes, at nanomolar concentrations of protein, inhibited invasion of human erythrocytes in vitro by the malaria parasite Plasmodium falciparum. Liposomes containing human band 3 were ten times more effective in inhibiting invasion than those with pig band 3 and six times more effective than liposomes containing human erythrocyte glycophorin. Liposomes alone or liposomes containing erythrocyte glycolipids did not inhibit invasion. These results suggest that band 3 participates in the invasion process in a step involving a specific, high-affinity interaction between band 3 and some component of the parasite.

Full Text

Duke Authors

Cited Authors

  • Okoye, VC; Bennett, V

Published Date

  • January 11, 1985

Published In

Volume / Issue

  • 227 / 4683

Start / End Page

  • 169 - 171

PubMed ID

  • 3880920

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.3880920


  • eng

Conference Location

  • United States