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Monoclonal antibody interaction with the third immunoglobulin-like domain of N-CAM is sufficient to cause cell migration.

Publication ,  Journal Article
Ackley, RL; Madison, RD; Archibald, SJ; Hemperly, JJ
Published in: Mol Cell Neurosci
1997

Cellular adhesion molecules can influence a variety of biological mechanisms in the nervous system. These range from the processes of normal development and maintenance to neural plasticity and recovery following injury. The elucidation of the intricate contributions of these molecules will require the correlation of functional assays with specific molecules and the specific binding domains of such molecules with multiple signaling pathways. The data presented in this paper show that the monoclonal antibody anti-NCAM16, directed against the third immunoglobulin-like domain of the neural cell adhesion molecule N-CAM, is capable of stimulating the complex biological process of cell migration in primary embryonic motor neurons and human neuronal cell lines.

Duke Scholars

Published In

Mol Cell Neurosci

DOI

ISSN

1044-7431

Publication Date

1997

Volume

10

Issue

1-2

Start / End Page

117 / 129

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Tissue Extracts
  • Recombinant Fusion Proteins
  • Rats, Sprague-Dawley
  • Rats
  • Peptide Fragments
  • Neurons
  • Neurology & Neurosurgery
  • Neural Cell Adhesion Molecules
  • Nerve Growth Factors
 

Citation

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MLA
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Ackley, R. L., Madison, R. D., Archibald, S. J., & Hemperly, J. J. (1997). Monoclonal antibody interaction with the third immunoglobulin-like domain of N-CAM is sufficient to cause cell migration. Mol Cell Neurosci, 10(1–2), 117–129. https://doi.org/10.1006/mcne.1997.0645
Ackley, R. L., R. D. Madison, S. J. Archibald, and J. J. Hemperly. “Monoclonal antibody interaction with the third immunoglobulin-like domain of N-CAM is sufficient to cause cell migration.Mol Cell Neurosci 10, no. 1–2 (1997): 117–29. https://doi.org/10.1006/mcne.1997.0645.
Ackley RL, Madison RD, Archibald SJ, Hemperly JJ. Monoclonal antibody interaction with the third immunoglobulin-like domain of N-CAM is sufficient to cause cell migration. Mol Cell Neurosci. 1997;10(1–2):117–29.
Ackley, R. L., et al. “Monoclonal antibody interaction with the third immunoglobulin-like domain of N-CAM is sufficient to cause cell migration.Mol Cell Neurosci, vol. 10, no. 1–2, 1997, pp. 117–29. Pubmed, doi:10.1006/mcne.1997.0645.
Ackley RL, Madison RD, Archibald SJ, Hemperly JJ. Monoclonal antibody interaction with the third immunoglobulin-like domain of N-CAM is sufficient to cause cell migration. Mol Cell Neurosci. 1997;10(1–2):117–129.
Journal cover image

Published In

Mol Cell Neurosci

DOI

ISSN

1044-7431

Publication Date

1997

Volume

10

Issue

1-2

Start / End Page

117 / 129

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Tissue Extracts
  • Recombinant Fusion Proteins
  • Rats, Sprague-Dawley
  • Rats
  • Peptide Fragments
  • Neurons
  • Neurology & Neurosurgery
  • Neural Cell Adhesion Molecules
  • Nerve Growth Factors