Monoclonal antibody interaction with the third immunoglobulin-like domain of N-CAM is sufficient to cause cell migration.

Journal Article (Journal Article)

Cellular adhesion molecules can influence a variety of biological mechanisms in the nervous system. These range from the processes of normal development and maintenance to neural plasticity and recovery following injury. The elucidation of the intricate contributions of these molecules will require the correlation of functional assays with specific molecules and the specific binding domains of such molecules with multiple signaling pathways. The data presented in this paper show that the monoclonal antibody anti-NCAM16, directed against the third immunoglobulin-like domain of the neural cell adhesion molecule N-CAM, is capable of stimulating the complex biological process of cell migration in primary embryonic motor neurons and human neuronal cell lines.

Full Text

Duke Authors

Cited Authors

  • Ackley, RL; Madison, RD; Archibald, SJ; Hemperly, JJ

Published Date

  • 1997

Published In

Volume / Issue

  • 10 / 1-2

Start / End Page

  • 117 - 129

PubMed ID

  • 9361292

International Standard Serial Number (ISSN)

  • 1044-7431

Digital Object Identifier (DOI)

  • 10.1006/mcne.1997.0645


  • eng

Conference Location

  • United States