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Reduction in transplant-related complications in patients given intravenous immuno globulin after allogeneic marrow transplantation.

Publication ,  Journal Article
Siadak, MF; Kopecky, K; Sullivan, KM
Published in: Clin Exp Immunol
July 1994

Bone marrow transplantation renders patients immunocompetent due to the need for supralethal doses of chemoradiotherapy prior to infusion of the donor stem cells. Multiple immunological deficiencies are seen and patients are at high risk of developing a variety of infections. This period of immunological incompetence usually lasts from 6 to 12 months. In some subsets of patients [those with chronic graft-versus-host disease (GVHD); recipients of unrelated transplants; increasing patient age] persistent T and B cell abnormalities may be seen for years, despite normal serum immunoglobulin levels. This review summarizes a number of trials of intravenous immune globulin (IVIG) therapy to prevent infection following bone marrow transplantation. IVIG has shown benefit in reducing septicaemia, interstitial pneumonia, fatal cytomegalovirus (CMV) disease, acute GVHD and transplant-related mortality in adult recipients of related marrow transplants. Further investigation into dose, schedule and duration of IVIG prophylaxis needs to be conducted.

Duke Scholars

Published In

Clin Exp Immunol

ISSN

0009-9104

Publication Date

July 1994

Volume

97 Suppl 1

Issue

Suppl 1

Start / End Page

53 / 57

Location

England

Related Subject Headings

  • Transplantation, Homologous
  • Immunology
  • Immunoglobulins, Intravenous
  • Humans
  • Graft vs Host Disease
  • Cytomegalovirus Infections
  • Clinical Trials as Topic
  • Bone Marrow Transplantation
  • 3204 Immunology
  • 1107 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Siadak, M. F., Kopecky, K., & Sullivan, K. M. (1994). Reduction in transplant-related complications in patients given intravenous immuno globulin after allogeneic marrow transplantation. Clin Exp Immunol, 97 Suppl 1(Suppl 1), 53–57.
Siadak, M. F., K. Kopecky, and K. M. Sullivan. “Reduction in transplant-related complications in patients given intravenous immuno globulin after allogeneic marrow transplantation.Clin Exp Immunol 97 Suppl 1, no. Suppl 1 (July 1994): 53–57.
Siadak MF, Kopecky K, Sullivan KM. Reduction in transplant-related complications in patients given intravenous immuno globulin after allogeneic marrow transplantation. Clin Exp Immunol. 1994 Jul;97 Suppl 1(Suppl 1):53–7.
Siadak, M. F., et al. “Reduction in transplant-related complications in patients given intravenous immuno globulin after allogeneic marrow transplantation.Clin Exp Immunol, vol. 97 Suppl 1, no. Suppl 1, July 1994, pp. 53–57.
Siadak MF, Kopecky K, Sullivan KM. Reduction in transplant-related complications in patients given intravenous immuno globulin after allogeneic marrow transplantation. Clin Exp Immunol. 1994 Jul;97 Suppl 1(Suppl 1):53–57.
Journal cover image

Published In

Clin Exp Immunol

ISSN

0009-9104

Publication Date

July 1994

Volume

97 Suppl 1

Issue

Suppl 1

Start / End Page

53 / 57

Location

England

Related Subject Headings

  • Transplantation, Homologous
  • Immunology
  • Immunoglobulins, Intravenous
  • Humans
  • Graft vs Host Disease
  • Cytomegalovirus Infections
  • Clinical Trials as Topic
  • Bone Marrow Transplantation
  • 3204 Immunology
  • 1107 Immunology