Irritant symptoms and immunologic responses to multiple chemicals: importance of clinical and immunologic correlations.


Journal Article

An evaluation of workers in a plant was conducted because of multiple complaints of ocular, nasal, skin and chest symptoms. Antibody activity against 4 different chemicals was identified: an aliphatic diisocyanate, 4-vinylcyclohexene dioxide, trimellitic anhydride (TMA) and an unknown chemical present in a plasticizing ester known as n-octyl-n-decyl-trimellitate. The source of TMA which resulted in immunization in the plant is unknown. The presence or absence of antibodies did not correlate with the presence or absence of symptoms and it was concluded that no occupational allergic disease was present in these workers. Antibody studies alone do not make a diagnosis of occupational allergic disease and clinical correlation is required. Immunoassays may be useful in identifying exposures to immunizing chemicals in the workplace for potential clinical correlation or for exposure monitoring in the workplace.

Full Text

Cited Authors

  • Patterson, R; Harris, KE; Stopford, W; Van der Heiden, G; Grammer, LC; Bunn, W

Published Date

  • 1988

Published In

Volume / Issue

  • 85 / 4

Start / End Page

  • 467 - 471

PubMed ID

  • 3356477

Pubmed Central ID

  • 3356477

International Standard Serial Number (ISSN)

  • 0020-5915

Digital Object Identifier (DOI)

  • 10.1159/000234553


  • eng

Conference Location

  • Switzerland