Enhanced tyrosine phosphorylation in B lymphocytes upon complexing of membrane immunoglobulin.


Journal Article

Activation of normal human peripheral blood B-enriched lymphocytes with antiserum reacting with membrane immunoglobulin was associated with increased phosphorylation of cellular proteins, particularly in the Triton-insoluble cytoskeletal fraction. At least two proteins (56K and 60K) were labeled predominantly at tyrosine residues. These findings may indicate another specialized membrane structure which upon specific ligand binding stimulates tyrosine phosphorylation in association with cellular proliferation.

Full Text

Cited Authors

  • Nel, AE; Landreth, GE; Goldschmidt-Clermont, PJ; Tung, HE; Galbraith, RM

Published Date

  • December 1984

Published In

Volume / Issue

  • 125 / 3

Start / End Page

  • 859 - 866

PubMed ID

  • 6335036

Pubmed Central ID

  • 6335036

Electronic International Standard Serial Number (EISSN)

  • 1090-2104

International Standard Serial Number (ISSN)

  • 0006-291X

Digital Object Identifier (DOI)

  • 10.1016/0006-291x(84)91362-7


  • eng