Translocation of phospholipid/Ca2+-dependent protein kinase in B-lymphocytes activated by phorbol ester or cross-linking of membrane immunoglobulin.


Journal Article

Stimulation of peripheral-blood B-lymphocytes with phorbol ester or anti-immunoglobulin demonstrated intracellular translocation of phospholipid/Ca2+-dependent protein kinase (C-kinase) activity from cytosol to membrane fractions. This phenomenon, which was dose- and time-dependent, was found in both normal and chronic-lymphocytic-leukemia B-cells. This suggests that C-kinase-dependent protein phosphorylation may be related to membrane receptor occupation and may therefore be important in B-lymphocyte responses.

Full Text

Cited Authors

  • Nel, AE; Wooten, MW; Landreth, GE; Goldschmidt-Clermont, PJ; Stevenson, HC; Miller, PJ; Galbraith, RM

Published Date

  • January 1, 1986

Published In

Volume / Issue

  • 233 / 1

Start / End Page

  • 145 - 149

PubMed ID

  • 3485425

Pubmed Central ID

  • 3485425

Electronic International Standard Serial Number (EISSN)

  • 1470-8728

International Standard Serial Number (ISSN)

  • 0264-6021

Digital Object Identifier (DOI)

  • 10.1042/bj2330145


  • eng