Proportion of circulating Gc (vitamin D-binding protein) in complexed form: relation to clinical outcome in fulminant hepatic necrosis.


Journal Article

Alterations in circulating levels of vitamin D-binding protein (Gc) and the percentage of Gc in complexed form were further studied in normal subjects and in patients with fulminant hepatic necrosis in relation to clinical outcome. Levels of Gc were markedly reduced in all 7 patients studied, particularly in nonsurvivors. The percentage of Gc in complexed form was generally less than 10% in normal subjects. However, complexes were increased in all patients, and the percentage correlated strongly with clinical outcome, being 22% +/- 7.3% in survivors and 72% +/- 7.5% in those who died (p less than 0.001). These results provide further evidence that Gc plays an important role in complexing and clearance of cellular actin released during tissue necrosis.

Full Text

Cited Authors

  • Goldschmidt-Clermont, PJ; Lee, WM; Galbraith, RM

Published Date

  • June 1988

Published In

Volume / Issue

  • 94 / 6

Start / End Page

  • 1454 - 1458

PubMed ID

  • 3360266

Pubmed Central ID

  • 3360266

Electronic International Standard Serial Number (EISSN)

  • 1528-0012

International Standard Serial Number (ISSN)

  • 0016-5085

Digital Object Identifier (DOI)

  • 10.1016/0016-5085(88)90686-5


  • eng