DNA methylation and atherosclerosis.


Journal Article (Review)

DNA methylation is a major epigenetic modification of the genome that has the potential to silence gene expression. Recently, the role of epigenetic alteration as a distinct and crucial mechanism to regulate genes governing cell proliferation in atherosclerosis has emerged. Aberrant methylation is related to aging, and, because it affects a large number of CpG islands, age-related methylation may be an important contributor to increased atherosclerosis among older individuals by upregulating atherosclerosis-susceptible genes and downregulating atherosclerosis-protective genes. Further dissection of epigenetic alterations in atherosclerosis and aging will lead to the identification of novel epigenetic modifiers and improved diagnosis and treatment for atherosclerosis-related diseases.

Full Text

Cited Authors

  • Dong, C; Yoon, W; Goldschmidt-Clermont, PJ

Published Date

  • August 2002

Published In

Volume / Issue

  • 132 / 8 Suppl

Start / End Page

  • 2406S - 2409S

PubMed ID

  • 12163701

Pubmed Central ID

  • 12163701

Electronic International Standard Serial Number (EISSN)

  • 1541-6100

International Standard Serial Number (ISSN)

  • 0022-3166

Digital Object Identifier (DOI)

  • 10.1093/jn/132.8.2406s


  • eng