Acute febrile cerebrovasculitis. A non-spotted fever group rickettsial disease.


Journal Article

In December 1985, a patient was seen with an illness that was clinically compatible with the recently described clinical syndrome of acute febrile cerebrovasculitis, including fever, headache, altered mentation, multifocal neurologic signs, and cerebrospinal fluid pleocytosis. An extensive medical evaluation failed to reveal a cause, until, retrospectively, she was shown to have antibodies to Rickettsia typhi. Detailed serologic analysis with enzyme immunoassays and protein immunoblots indicated that she was infected with a non-spotted fever group Rickettsia, most likely either R typhi or Rickettsia canada. Serum samples from a mouse trapped at her home contained antibody only to R canada. Evaluation of patients with acute febrile cerebrovasculitis in the future should include rickettsial blood cultures to attempt specific identification of the species involved.

Full Text

Duke Authors

Cited Authors

  • Linnemann, CC; Pretzman, CI; Peterson, ED

Published Date

  • July 1, 1989

Published In

Volume / Issue

  • 149 / 7

Start / End Page

  • 1682 - 1684

PubMed ID

  • 2742443

Pubmed Central ID

  • 2742443

International Standard Serial Number (ISSN)

  • 0003-9926

Digital Object Identifier (DOI)

  • 10.1001/archinte.149.7.1682


  • eng

Conference Location

  • United States