IgE Fc receptor positive T, B and NK cells in patients with the hyper-IgE syndrome.

Published

Journal Article

Patients with the hyper-IgE syndrome have greatly elevated percentages of IgE Fc receptor (Fc epsilon R)-positive B cells, but they have less than 0.1% Fc epsilon R+ T cells (T epsilon cells) and few, if any, Fc epsilon R+ natural killer cells. They also have markedly decreased numbers of IgG receptor positive (Fc gamma R+) T cells (T gamma cells). Patients with the hyper-IgE syndrome resemble in this respect patients with severe atopic dermatitis. Since a portion of T epsilon and T gamma cells of mildly atopic patients react with monoclonal antibody OKT8, they may have a suppressor function. However, whether the low number of T epsilon cells is responsible for the high IgE serum level in hyper-IgE syndrome and atopic dermatitis patients remains to be demonstrated. Attempts to obtain a reliable assay for human IgE synthesis in vitro to investigate the function of Fc epsilon R-positive lymphocytes proved to be difficult. Even isolated B cells from atopic donors seldom produced more than twice the quantity of IgE released from cells incubated in the presence of the protein synthesis inhibitor cycloheximide.

Full Text

Duke Authors

Cited Authors

  • Spiegelberg, HL; Thompson, LF; McNeil, D; Buckley, RH

Published Date

  • 1985

Published In

Volume / Issue

  • 77 / 1-2

Start / End Page

  • 277 - 279

PubMed ID

  • 3159686

Pubmed Central ID

  • 3159686

International Standard Serial Number (ISSN)

  • 0020-5915

Language

  • eng

Conference Location

  • Switzerland