Persistent and fatal central-nervous-system ECHOvirus infections in patients with agammaglobulinemia.

Journal Article (Journal Article)

We observed persistent ECHOvirus infection of the central nervous system, as defined by continued presence of isolatable virus in cerebrospinal fluid, in five patients with agammaglobulinemia. The immunologic deficit in each was characterized by absence of surface-immunoglobulin-bearing B lymphocytes and of lymph-node cortical follicles, but normal T-cell function. ECHOviruses 30, 19, 9 and 33 were recovered from cerebrospinal fluid for periods varying from two months to three years. The patients had few signs of acute central-nervous-system infection. Three of the five patients had a dermatomyositis-like syndrome, with peripheral lymphocytes that reacted with anti-human leukemia-specific primate and rabbit serums in a cytotoxicity assay. These data suggest that intact B-cell function is essential for eradication of ECHOvirus infection of the central nervous system.

Full Text

Duke Authors

Cited Authors

  • Wilfert, CM; Buckley, RH; Mohanakumar, T; Griffith, JF; Katz, SL; Whisnant, JK; Eggleston, PA; Moore, M; Treadwell, E; Oxman, MN; Rosen, FS

Published Date

  • June 30, 1977

Published In

Volume / Issue

  • 296 / 26

Start / End Page

  • 1485 - 1489

PubMed ID

  • 301244

International Standard Serial Number (ISSN)

  • 0028-4793

Digital Object Identifier (DOI)

  • 10.1056/NEJM197706302962601


  • eng

Conference Location

  • United States