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Persistent and fatal central-nervous-system ECHOvirus infections in patients with agammaglobulinemia.

Publication ,  Journal Article
Wilfert, CM; Buckley, RH; Mohanakumar, T; Griffith, JF; Katz, SL; Whisnant, JK; Eggleston, PA; Moore, M; Treadwell, E; Oxman, MN; Rosen, FS
Published in: N Engl J Med
June 30, 1977

We observed persistent ECHOvirus infection of the central nervous system, as defined by continued presence of isolatable virus in cerebrospinal fluid, in five patients with agammaglobulinemia. The immunologic deficit in each was characterized by absence of surface-immunoglobulin-bearing B lymphocytes and of lymph-node cortical follicles, but normal T-cell function. ECHOviruses 30, 19, 9 and 33 were recovered from cerebrospinal fluid for periods varying from two months to three years. The patients had few signs of acute central-nervous-system infection. Three of the five patients had a dermatomyositis-like syndrome, with peripheral lymphocytes that reacted with anti-human leukemia-specific primate and rabbit serums in a cytotoxicity assay. These data suggest that intact B-cell function is essential for eradication of ECHOvirus infection of the central nervous system.

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Published In

N Engl J Med

DOI

ISSN

0028-4793

Publication Date

June 30, 1977

Volume

296

Issue

26

Start / End Page

1485 / 1489

Location

United States

Related Subject Headings

  • Receptors, Antigen, B-Cell
  • Male
  • Lymph Nodes
  • Infant
  • Humans
  • General & Internal Medicine
  • Female
  • Enterovirus B, Human
  • Echovirus Infections
  • Echovirus 9
 

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Wilfert, C. M., Buckley, R. H., Mohanakumar, T., Griffith, J. F., Katz, S. L., Whisnant, J. K., … Rosen, F. S. (1977). Persistent and fatal central-nervous-system ECHOvirus infections in patients with agammaglobulinemia. N Engl J Med, 296(26), 1485–1489. https://doi.org/10.1056/NEJM197706302962601
Wilfert, C. M., R. H. Buckley, T. Mohanakumar, J. F. Griffith, S. L. Katz, J. K. Whisnant, P. A. Eggleston, et al. “Persistent and fatal central-nervous-system ECHOvirus infections in patients with agammaglobulinemia.N Engl J Med 296, no. 26 (June 30, 1977): 1485–89. https://doi.org/10.1056/NEJM197706302962601.
Wilfert CM, Buckley RH, Mohanakumar T, Griffith JF, Katz SL, Whisnant JK, et al. Persistent and fatal central-nervous-system ECHOvirus infections in patients with agammaglobulinemia. N Engl J Med. 1977 Jun 30;296(26):1485–9.
Wilfert, C. M., et al. “Persistent and fatal central-nervous-system ECHOvirus infections in patients with agammaglobulinemia.N Engl J Med, vol. 296, no. 26, June 1977, pp. 1485–89. Pubmed, doi:10.1056/NEJM197706302962601.
Wilfert CM, Buckley RH, Mohanakumar T, Griffith JF, Katz SL, Whisnant JK, Eggleston PA, Moore M, Treadwell E, Oxman MN, Rosen FS. Persistent and fatal central-nervous-system ECHOvirus infections in patients with agammaglobulinemia. N Engl J Med. 1977 Jun 30;296(26):1485–1489.
Journal cover image

Published In

N Engl J Med

DOI

ISSN

0028-4793

Publication Date

June 30, 1977

Volume

296

Issue

26

Start / End Page

1485 / 1489

Location

United States

Related Subject Headings

  • Receptors, Antigen, B-Cell
  • Male
  • Lymph Nodes
  • Infant
  • Humans
  • General & Internal Medicine
  • Female
  • Enterovirus B, Human
  • Echovirus Infections
  • Echovirus 9