Fungal infection in chronic granulomatous disease. The importance of the phagocyte in defense against fungi.

Journal Article (Journal Article)

Among 245 cases of chronic granulomatous disease which were evaluated, fungal infection occurred in 20.4 percent. Fungi encountered include Aspergillus, Torulopsis and Candida. In 18 percent of the patients with fungal infection, the disease was limited to soft tissue or bone; all did well. Most of the patients had fungal pneumonia and/or widely disseminated disease; diagnosis was usually confirmed by open lung biopsy. Patients with pneumonia or disseminated disease who received no therapy succumbed to infection, whereas more than half the patients who received antifungal therapy were cured. Modalities of treatment included antifungal chemotherapy, surgical removal of infected tissue and granulocyte transfusion. Although several patients showed dramatic improvement during granulocyte transfusions given in combination with antifungal chemotherapy, the improvement achieved was not statistically significant when compared with that achieved with chemotherapy alone. These results emphasized the importance of phagocytic cells in defense against fungi and the need for further evaluation of granulocyte transfusion therapy in compromised hosts in whom fungal infections develop.

Full Text

Duke Authors

Cited Authors

  • Cohen, MS; Isturiz, RE; Malech, HL; Root, RK; Wilfert, CM; Gutman, L; Buckley, RH

Published Date

  • July 1, 1981

Published In

Volume / Issue

  • 71 / 1

Start / End Page

  • 59 - 66

PubMed ID

  • 7195647

International Standard Serial Number (ISSN)

  • 0002-9343

Digital Object Identifier (DOI)

  • 10.1016/0002-9343(81)90259-x


  • eng

Conference Location

  • United States