beta-Arrestin: a protein that regulates beta-adrenergic receptor function.

Published

Journal Article

Homologous or agonist-specific desensitization of beta-adrenergic receptors is thought to be mediated by a specific kinase, the beta-adrenergic receptor kinase (beta ARK). However, recent data suggest that a cofactor is required for this kinase to inhibit receptor function. The complementary DNA for such a cofactor was cloned and found to encode a 418-amino acid protein homologous to the retinal protein arrestin. The protein, termed beta-arrestin, was expressed and partially purified. It inhibited the signaling function of beta ARK-phosphorylated beta-adrenergic receptors by more than 75 percent, but not that of rhodopsin. It is proposed that beta-arrestin in concert with beta ARK effects homologous desensitization of beta-adrenergic receptors.

Full Text

Duke Authors

Cited Authors

  • Lohse, MJ; Benovic, JL; Codina, J; Caron, MG; Lefkowitz, RJ

Published Date

  • June 22, 1990

Published In

Volume / Issue

  • 248 / 4962

Start / End Page

  • 1547 - 1550

PubMed ID

  • 2163110

Pubmed Central ID

  • 2163110

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.2163110

Language

  • eng

Conference Location

  • United States