beta-Arrestin: a protein that regulates beta-adrenergic receptor function.
Journal Article (Journal Article)
Homologous or agonist-specific desensitization of beta-adrenergic receptors is thought to be mediated by a specific kinase, the beta-adrenergic receptor kinase (beta ARK). However, recent data suggest that a cofactor is required for this kinase to inhibit receptor function. The complementary DNA for such a cofactor was cloned and found to encode a 418-amino acid protein homologous to the retinal protein arrestin. The protein, termed beta-arrestin, was expressed and partially purified. It inhibited the signaling function of beta ARK-phosphorylated beta-adrenergic receptors by more than 75 percent, but not that of rhodopsin. It is proposed that beta-arrestin in concert with beta ARK effects homologous desensitization of beta-adrenergic receptors.
- Lohse, MJ; Benovic, JL; Codina, J; Caron, MG; Lefkowitz, RJ
- June 22, 1990
Volume / Issue
- 248 / 4962
Start / End Page
- 1547 - 1550
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States