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beta-Arrestin: a protein that regulates beta-adrenergic receptor function.

Publication ,  Journal Article
Lohse, MJ; Benovic, JL; Codina, J; Caron, MG; Lefkowitz, RJ
Published in: Science
June 22, 1990

Homologous or agonist-specific desensitization of beta-adrenergic receptors is thought to be mediated by a specific kinase, the beta-adrenergic receptor kinase (beta ARK). However, recent data suggest that a cofactor is required for this kinase to inhibit receptor function. The complementary DNA for such a cofactor was cloned and found to encode a 418-amino acid protein homologous to the retinal protein arrestin. The protein, termed beta-arrestin, was expressed and partially purified. It inhibited the signaling function of beta ARK-phosphorylated beta-adrenergic receptors by more than 75 percent, but not that of rhodopsin. It is proposed that beta-arrestin in concert with beta ARK effects homologous desensitization of beta-adrenergic receptors.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

June 22, 1990

Volume

248

Issue

4962

Start / End Page

1547 / 1550

Location

United States

Related Subject Headings

  • beta-Adrenergic Receptor Kinases
  • Transfection
  • Receptors, Adrenergic, beta
  • RNA, Messenger
  • Protein Kinases
  • Phosphorylation
  • Phosphodiesterase Inhibitors
  • Molecular Sequence Data
  • General Science & Technology
  • Gene Expression Regulation
 

Citation

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Lohse, M. J., Benovic, J. L., Codina, J., Caron, M. G., & Lefkowitz, R. J. (1990). beta-Arrestin: a protein that regulates beta-adrenergic receptor function. Science, 248(4962), 1547–1550. https://doi.org/10.1126/science.2163110
Lohse, M. J., J. L. Benovic, J. Codina, M. G. Caron, and R. J. Lefkowitz. “beta-Arrestin: a protein that regulates beta-adrenergic receptor function.Science 248, no. 4962 (June 22, 1990): 1547–50. https://doi.org/10.1126/science.2163110.
Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ. beta-Arrestin: a protein that regulates beta-adrenergic receptor function. Science. 1990 Jun 22;248(4962):1547–50.
Lohse, M. J., et al. “beta-Arrestin: a protein that regulates beta-adrenergic receptor function.Science, vol. 248, no. 4962, June 1990, pp. 1547–50. Pubmed, doi:10.1126/science.2163110.
Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ. beta-Arrestin: a protein that regulates beta-adrenergic receptor function. Science. 1990 Jun 22;248(4962):1547–1550.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

June 22, 1990

Volume

248

Issue

4962

Start / End Page

1547 / 1550

Location

United States

Related Subject Headings

  • beta-Adrenergic Receptor Kinases
  • Transfection
  • Receptors, Adrenergic, beta
  • RNA, Messenger
  • Protein Kinases
  • Phosphorylation
  • Phosphodiesterase Inhibitors
  • Molecular Sequence Data
  • General Science & Technology
  • Gene Expression Regulation