Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins.

Published

Journal Article (Review)

Sequestration of G protein-coupled receptors from the cell surface is a commonly observed phenomenon following agonist-stimulation. This process is now believed to be important for receptor resensitization as well as for signal transduction. Over the years, numerous studies have aimed at understanding the molecular mechanisms underlying internalization. Proteins such as the G protein-coupled receptor kinases (GRKs) and the beta-arrestins, which were initially characterized as desensitizing molecules, have been shown to be important regulators of the endocytic process. Recently, numerous interacting partners have been identified for each of these two classes of proteins. However, the details regarding the sequence of these interactions and the cross-talk between signaling pathways containing the different protein complexes are just beginning to be uncovered. In this review, we summarize these findings and discuss the role of GRKs and beta-arrestins, two families of key regulatory proteins that regulate G protein-coupled receptor endocytosis.

Full Text

Duke Authors

Cited Authors

  • Claing, A; Laporte, SA; Caron, MG; Lefkowitz, RJ

Published Date

  • February 2002

Published In

Volume / Issue

  • 66 / 2

Start / End Page

  • 61 - 79

PubMed ID

  • 11900882

Pubmed Central ID

  • 11900882

International Standard Serial Number (ISSN)

  • 0301-0082

Language

  • eng

Conference Location

  • England