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Turning off the signal: desensitization of beta-adrenergic receptor function.

Publication ,  Journal Article
Hausdorff, WP; Caron, MG; Lefkowitz, RJ
Published in: FASEB J
August 1990

Cellular responses to many hormones and neurotransmitters wane rapidly despite continuous exposure of cells to these stimuli. This phenomenon, termed desensitization, has been particularly well studied for the stimulation of cAMP levels by plasma membrane beta-adrenergic receptors (beta AR). The molecular mechanisms underlying rapid beta AR desensitization do not appear to require internalization of the receptors, but rather an alteration in the functioning of beta AR themselves that uncouples the receptors from the stimulatory G protein Gs. This uncoupling phenomenon involves phosphorylation of beta AR by at least two kinases, PKA and the beta AR kinase (beta ARK), which are activated under different desensitizing conditions. Receptor phosphorylation by the two kinases leads to desensitization of the receptor response via distinct biochemical mechanisms, and additional cytosolic factors appear to be involved in the case of beta ARK. Numerous experimental approaches have been used recently to elucidate the molecular details of this ubiquitous biological process.

Duke Scholars

Published In

FASEB J

ISSN

0892-6638

Publication Date

August 1990

Volume

4

Issue

11

Start / End Page

2881 / 2889

Location

United States

Related Subject Headings

  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Protein Kinases
  • Protein Conformation
  • Molecular Sequence Data
  • Models, Biological
  • Humans
  • Cyclic AMP
  • Biochemistry & Molecular Biology
  • Animals
 

Citation

APA
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ICMJE
MLA
NLM
Hausdorff, W. P., Caron, M. G., & Lefkowitz, R. J. (1990). Turning off the signal: desensitization of beta-adrenergic receptor function. FASEB J, 4(11), 2881–2889.
Hausdorff, W. P., M. G. Caron, and R. J. Lefkowitz. “Turning off the signal: desensitization of beta-adrenergic receptor function.FASEB J 4, no. 11 (August 1990): 2881–89.
Hausdorff WP, Caron MG, Lefkowitz RJ. Turning off the signal: desensitization of beta-adrenergic receptor function. FASEB J. 1990 Aug;4(11):2881–9.
Hausdorff, W. P., et al. “Turning off the signal: desensitization of beta-adrenergic receptor function.FASEB J, vol. 4, no. 11, Aug. 1990, pp. 2881–89.
Hausdorff WP, Caron MG, Lefkowitz RJ. Turning off the signal: desensitization of beta-adrenergic receptor function. FASEB J. 1990 Aug;4(11):2881–2889.

Published In

FASEB J

ISSN

0892-6638

Publication Date

August 1990

Volume

4

Issue

11

Start / End Page

2881 / 2889

Location

United States

Related Subject Headings

  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Protein Kinases
  • Protein Conformation
  • Molecular Sequence Data
  • Models, Biological
  • Humans
  • Cyclic AMP
  • Biochemistry & Molecular Biology
  • Animals