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Structure of the adrenergic and related receptors.

Publication ,  Journal Article
O'Dowd, BF; Lefkowitz, RJ; Caron, MG
Published in: Annu Rev Neurosci
1989

The isolation and sequencing of a number of G protein-coupled receptors has now provided extensive primary structure information for this family of homologous proteins. The diverse nature of these receptors suggests that the family of proteins may grow to include receptors for many neurotransmitters and perhaps many peptide hormones. The topography of these receptors, a single polypeptide with seven transmembrane segments, appears to have features well suited for the transmission of signals, via conformational changes, to the interior of the cell. Detailed site-directed mutagenesis studies are now underway in many laboratories to understand the significance of the topography and also the regions of homology evident in the structures of all of these receptors. Obvious features of interest are the precise residues involved in the coupling of the receptors to the G-proteins and the identification of the residues required for ligand binding in each of the receptors, as well as domains of these receptors involved in the regulation of receptor function. In addition, the availability of molecular probes for this family of proteins will permit the elucidation of mechanisms of regulation at the gene level.

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Published In

Annu Rev Neurosci

DOI

ISSN

0147-006X

Publication Date

1989

Volume

12

Start / End Page

67 / 83

Location

United States

Related Subject Headings

  • Receptors, Muscarinic
  • Receptors, Adrenergic
  • Protein Conformation
  • Neurology & Neurosurgery
  • Molecular Sequence Data
  • Animals
  • Amino Acid Sequence
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
 

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O’Dowd, B. F., Lefkowitz, R. J., & Caron, M. G. (1989). Structure of the adrenergic and related receptors. Annu Rev Neurosci, 12, 67–83. https://doi.org/10.1146/annurev.ne.12.030189.000435
O’Dowd, B. F., R. J. Lefkowitz, and M. G. Caron. “Structure of the adrenergic and related receptors.Annu Rev Neurosci 12 (1989): 67–83. https://doi.org/10.1146/annurev.ne.12.030189.000435.
O’Dowd BF, Lefkowitz RJ, Caron MG. Structure of the adrenergic and related receptors. Annu Rev Neurosci. 1989;12:67–83.
O’Dowd, B. F., et al. “Structure of the adrenergic and related receptors.Annu Rev Neurosci, vol. 12, 1989, pp. 67–83. Pubmed, doi:10.1146/annurev.ne.12.030189.000435.
O’Dowd BF, Lefkowitz RJ, Caron MG. Structure of the adrenergic and related receptors. Annu Rev Neurosci. 1989;12:67–83.

Published In

Annu Rev Neurosci

DOI

ISSN

0147-006X

Publication Date

1989

Volume

12

Start / End Page

67 / 83

Location

United States

Related Subject Headings

  • Receptors, Muscarinic
  • Receptors, Adrenergic
  • Protein Conformation
  • Neurology & Neurosurgery
  • Molecular Sequence Data
  • Animals
  • Amino Acid Sequence
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences