Guanine nucleotides regulate both dopaminergic agonist and antagonist binding in porcine anterior pituitary.
Published
Journal Article
Radiolabelled agonist and antagonist binding to porcine anterior pituitary dopaminergic receptor indicates the existence of two affinity forms of the receptor. These two forms of the receptor are modulated by guanine nucleotides. The agonist high affinity form of the receptor is converted to a low affinity form, whereas the antagonist low affinity form is converted to the high affinity form under the influence of guanine nucleotides. Thus, guanine nucleotides appear to reciprocally modulate the same two forms of the receptor discriminated by both agonists and antagonists. These observations may provide insights into the biochemical mechanism by which dopamine exerts its regulation of prolactin release in the anterior pituitary.
Full Text
Duke Authors
Cited Authors
- De Lean, A; Kilpatrick, BF; Caron, MG
Published Date
- March 1, 1982
Published In
Volume / Issue
- 110 / 3
Start / End Page
- 1064 - 1066
PubMed ID
- 7056223
Pubmed Central ID
- 7056223
International Standard Serial Number (ISSN)
- 0013-7227
Digital Object Identifier (DOI)
- 10.1210/endo-110-3-1064
Language
- eng
Conference Location
- United States