Guanine nucleotides regulate both dopaminergic agonist and antagonist binding in porcine anterior pituitary.


Journal Article

Radiolabelled agonist and antagonist binding to porcine anterior pituitary dopaminergic receptor indicates the existence of two affinity forms of the receptor. These two forms of the receptor are modulated by guanine nucleotides. The agonist high affinity form of the receptor is converted to a low affinity form, whereas the antagonist low affinity form is converted to the high affinity form under the influence of guanine nucleotides. Thus, guanine nucleotides appear to reciprocally modulate the same two forms of the receptor discriminated by both agonists and antagonists. These observations may provide insights into the biochemical mechanism by which dopamine exerts its regulation of prolactin release in the anterior pituitary.

Full Text

Duke Authors

Cited Authors

  • De Lean, A; Kilpatrick, BF; Caron, MG

Published Date

  • March 1, 1982

Published In

Volume / Issue

  • 110 / 3

Start / End Page

  • 1064 - 1066

PubMed ID

  • 7056223

Pubmed Central ID

  • 7056223

International Standard Serial Number (ISSN)

  • 0013-7227

Digital Object Identifier (DOI)

  • 10.1210/endo-110-3-1064


  • eng

Conference Location

  • United States