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Adrenergic receptor homologies in vertebrate and invertebrate species examined by DNA hybridization.

Publication ,  Journal Article
Palacios, JM; O'Dowd, BF; Cotecchia, S; Hnatowich, M; Caron, MG; Lefkowitz, RJ
Published in: Life Sci
1989

The deduced protein sequences of the mammalian adrenergic receptors (ARs) suggest that these proteins have evolved by several ancient gene duplication events. To investigate in what species these events may have occurred DNA fragments encoding the family of adrenergic receptors from human (beta 1AR and alpha 2AR) and hamster (beta 2AR and alpha 1AR) were used to detect homologous sequences in other vertebrates, invertebrates and unicellular organisms by Southern blot hybridization analysis. Sequences homologous to hamster beta 2AR were detected in lower vertebrates, invertebrates and Dictyostelium, but not in yeast or bacteria. Within vertebrates, sequences strongly homologous to human beta 1AR and human platelet alpha 2AR were confined to the higher vertebrates only. In the invertebrates, only Drosophila contained sequences homologous to hamster alpha 1AR. Our results suggest that non-mammalian species may contain receptors homologous to the mammalian adrenergic receptors and that the sequences homologous to human beta 2AR have been the most strongly conserved.

Duke Scholars

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

1989

Volume

44

Issue

26

Start / End Page

2057 / 2065

Location

Netherlands

Related Subject Headings

  • Sequence Homology, Nucleic Acid
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Pharmacology & Pharmacy
  • Nucleic Acid Hybridization
  • Dictyostelium
  • Blotting, Southern
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 3101 Biochemistry and cell biology
 

Citation

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Chicago
ICMJE
MLA
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Palacios, J. M., O’Dowd, B. F., Cotecchia, S., Hnatowich, M., Caron, M. G., & Lefkowitz, R. J. (1989). Adrenergic receptor homologies in vertebrate and invertebrate species examined by DNA hybridization. Life Sci, 44(26), 2057–2065. https://doi.org/10.1016/0024-3205(89)90352-4
Palacios, J. M., B. F. O’Dowd, S. Cotecchia, M. Hnatowich, M. G. Caron, and R. J. Lefkowitz. “Adrenergic receptor homologies in vertebrate and invertebrate species examined by DNA hybridization.Life Sci 44, no. 26 (1989): 2057–65. https://doi.org/10.1016/0024-3205(89)90352-4.
Palacios JM, O’Dowd BF, Cotecchia S, Hnatowich M, Caron MG, Lefkowitz RJ. Adrenergic receptor homologies in vertebrate and invertebrate species examined by DNA hybridization. Life Sci. 1989;44(26):2057–65.
Palacios, J. M., et al. “Adrenergic receptor homologies in vertebrate and invertebrate species examined by DNA hybridization.Life Sci, vol. 44, no. 26, 1989, pp. 2057–65. Pubmed, doi:10.1016/0024-3205(89)90352-4.
Palacios JM, O’Dowd BF, Cotecchia S, Hnatowich M, Caron MG, Lefkowitz RJ. Adrenergic receptor homologies in vertebrate and invertebrate species examined by DNA hybridization. Life Sci. 1989;44(26):2057–2065.
Journal cover image

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

1989

Volume

44

Issue

26

Start / End Page

2057 / 2065

Location

Netherlands

Related Subject Headings

  • Sequence Homology, Nucleic Acid
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Pharmacology & Pharmacy
  • Nucleic Acid Hybridization
  • Dictyostelium
  • Blotting, Southern
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 3101 Biochemistry and cell biology