Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression.

Journal Article (Journal Article;Review)

Multiple mechanisms contribute to the regulation of G protein-coupled receptors and their transmembrane signaling. Post-translational modifications of the receptors, such as phosphorylation, and changes in receptor gene expression can occur in either a strictly agonist-dependent fashion or through second messenger-mediated autoregulation. We have shown that modulation of receptor gene expression contributes to the responsiveness of adrenergic and related receptors. Recent evidence for post-transcriptional regulation, as well as the stimulation of transcription in an autoregulatory manner, indicates the unanticipated variety and complexity of mechanisms regulating adrenergic receptor responsiveness.

Full Text

Duke Authors

Cited Authors

  • Collins, S; Caron, MG; Lefkowitz, RJ

Published Date

  • 1991

Published In

Volume / Issue

  • 53 /

Start / End Page

  • 497 - 508

PubMed ID

  • 2042970

International Standard Serial Number (ISSN)

  • 0066-4278

Digital Object Identifier (DOI)

  • 10.1146/


  • eng

Conference Location

  • United States