Skip to main content

Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression.

Publication ,  Journal Article
Collins, S; Caron, MG; Lefkowitz, RJ
Published in: Annu Rev Physiol
1991

Multiple mechanisms contribute to the regulation of G protein-coupled receptors and their transmembrane signaling. Post-translational modifications of the receptors, such as phosphorylation, and changes in receptor gene expression can occur in either a strictly agonist-dependent fashion or through second messenger-mediated autoregulation. We have shown that modulation of receptor gene expression contributes to the responsiveness of adrenergic and related receptors. Recent evidence for post-transcriptional regulation, as well as the stimulation of transcription in an autoregulatory manner, indicates the unanticipated variety and complexity of mechanisms regulating adrenergic receptor responsiveness.

Duke Scholars

Published In

Annu Rev Physiol

DOI

ISSN

0066-4278

Publication Date

1991

Volume

53

Start / End Page

497 / 508

Location

United States

Related Subject Headings

  • Up-Regulation
  • Receptors, Adrenergic
  • Physiology
  • Humans
  • Gene Expression Regulation
  • Animals
  • 3208 Medical physiology
  • 3109 Zoology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Collins, S., Caron, M. G., & Lefkowitz, R. J. (1991). Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. Annu Rev Physiol, 53, 497–508. https://doi.org/10.1146/annurev.ph.53.030191.002433
Collins, S., M. G. Caron, and R. J. Lefkowitz. “Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression.Annu Rev Physiol 53 (1991): 497–508. https://doi.org/10.1146/annurev.ph.53.030191.002433.
Collins S, Caron MG, Lefkowitz RJ. Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. Annu Rev Physiol. 1991;53:497–508.
Collins, S., et al. “Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression.Annu Rev Physiol, vol. 53, 1991, pp. 497–508. Pubmed, doi:10.1146/annurev.ph.53.030191.002433.
Collins S, Caron MG, Lefkowitz RJ. Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. Annu Rev Physiol. 1991;53:497–508.

Published In

Annu Rev Physiol

DOI

ISSN

0066-4278

Publication Date

1991

Volume

53

Start / End Page

497 / 508

Location

United States

Related Subject Headings

  • Up-Regulation
  • Receptors, Adrenergic
  • Physiology
  • Humans
  • Gene Expression Regulation
  • Animals
  • 3208 Medical physiology
  • 3109 Zoology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences