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Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation.

Publication ,  Journal Article
Lefkowitz, RJ; Caron, MG
Published in: J Mol Cell Cardiol
September 1986

The various subtypes of adrenergic receptors represent distinct structural entities which are coupled in different ways to two major transmembrane signalling systems, the adenylate cyclase and phosphatidyl-inositol pathways. Recent evidence suggests that the functional linkage of both beta and alpha 1-adrenergic receptors to their respective effector systems is regulated by covalent modification of the receptors by phosphorylation-dephosphorylation reactions. Receptor phosphorylation appears to lead to desensitization of the biological response to receptor stimulation. Several kinases including protein kinase A, protein kinase C and a cAMP independent kinase appear to participate in these reactions.

Duke Scholars

Published In

J Mol Cell Cardiol

DOI

ISSN

0022-2828

Publication Date

September 1986

Volume

18

Issue

9

Start / End Page

885 / 895

Location

England

Related Subject Headings

  • Type C Phospholipases
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Receptors, Adrenergic
  • Protein Kinases
  • Protein Kinase C
  • Phosphorylation
  • Molecular Weight
  • Isoproterenol
  • GTP-Binding Proteins
 

Citation

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Lefkowitz, R. J., & Caron, M. G. (1986). Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation. J Mol Cell Cardiol, 18(9), 885–895. https://doi.org/10.1016/s0022-2828(86)80003-7
Lefkowitz, R. J., and M. G. Caron. “Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation.J Mol Cell Cardiol 18, no. 9 (September 1986): 885–95. https://doi.org/10.1016/s0022-2828(86)80003-7.
Lefkowitz, R. J., and M. G. Caron. “Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation.J Mol Cell Cardiol, vol. 18, no. 9, Sept. 1986, pp. 885–95. Pubmed, doi:10.1016/s0022-2828(86)80003-7.
Lefkowitz RJ, Caron MG. Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation. J Mol Cell Cardiol. 1986 Sep;18(9):885–895.
Journal cover image

Published In

J Mol Cell Cardiol

DOI

ISSN

0022-2828

Publication Date

September 1986

Volume

18

Issue

9

Start / End Page

885 / 895

Location

England

Related Subject Headings

  • Type C Phospholipases
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Receptors, Adrenergic
  • Protein Kinases
  • Protein Kinase C
  • Phosphorylation
  • Molecular Weight
  • Isoproterenol
  • GTP-Binding Proteins