Genetic regulation of beta-adrenergic receptors.

Published

Journal Article (Review)

Several members of the family of receptors coupled to G proteins have been cloned in recent years. From the primary sequence information furnished by these clones, a characteristic seven-membrane spanning topography has emerged as the prototype for this class of receptors, in analogy with the opsin visual pigments. Cloned genes for the various receptors provide important tools for probing the regulation of their expression. For example, the underlying genetic basis for the expression of adrenergic receptor subtypes can now be explored. The physiological regulation of receptors by heterologous hormones, such as steroids and thyroid hormones, has long been suspected to involve changes in the expression of the relevant adrenergic receptor genes. At least for the glucocorticoids, beta 2AR expression is controlled at the level of transcription. The hormonal regulation of other adrenergic receptor subtypes is currently being explored.

Full Text

Duke Authors

Cited Authors

  • Collins, S; Bolanowski, MA; Caron, MG; Lefkowitz, RJ

Published Date

  • 1989

Published In

Volume / Issue

  • 51 /

Start / End Page

  • 203 - 215

PubMed ID

  • 2540696

Pubmed Central ID

  • 2540696

International Standard Serial Number (ISSN)

  • 0066-4278

Digital Object Identifier (DOI)

  • 10.1146/annurev.ph.51.030189.001223

Language

  • eng

Conference Location

  • United States