Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor.


Journal Article

The gene for the human platelet alpha 2-adrenergic receptor has been cloned with oligonucleotides corresponding to the partial amino acid sequence of the purified receptor. The identity of this gene has been confirmed by the binding of alpha 2-adrenergic ligands to the cloned receptor expressed in Xenopus laevis oocytes. The deduced amino acid sequence is most similar to the recently cloned human beta 2- and beta 1-adrenergic receptors; however, similarities to the muscarinic cholinergic receptors are also evident. Two related genes have been identified by low stringency Southern blot analysis. These genes may represent additional alpha 2-adrenergic receptor subtypes.

Full Text

Duke Authors

Cited Authors

  • Kobilka, BK; Matsui, H; Kobilka, TS; Yang-Feng, TL; Francke, U; Caron, MG; Lefkowitz, RJ; Regan, JW

Published Date

  • October 30, 1987

Published In

Volume / Issue

  • 238 / 4827

Start / End Page

  • 650 - 656

PubMed ID

  • 2823383

Pubmed Central ID

  • 2823383

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.2823383


  • eng

Conference Location

  • United States