Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor.
Publication
, Journal Article
Kobilka, BK; Matsui, H; Kobilka, TS; Yang-Feng, TL; Francke, U; Caron, MG; Lefkowitz, RJ; Regan, JW
Published in: Science
October 30, 1987
The gene for the human platelet alpha 2-adrenergic receptor has been cloned with oligonucleotides corresponding to the partial amino acid sequence of the purified receptor. The identity of this gene has been confirmed by the binding of alpha 2-adrenergic ligands to the cloned receptor expressed in Xenopus laevis oocytes. The deduced amino acid sequence is most similar to the recently cloned human beta 2- and beta 1-adrenergic receptors; however, similarities to the muscarinic cholinergic receptors are also evident. Two related genes have been identified by low stringency Southern blot analysis. These genes may represent additional alpha 2-adrenergic receptor subtypes.
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Published In
Science
DOI
ISSN
0036-8075
Publication Date
October 30, 1987
Volume
238
Issue
4827
Start / End Page
650 / 656
Location
United States
Related Subject Headings
- Receptors, Adrenergic, alpha
- Phosphoproteins
- Oligodeoxyribonucleotides
- Multigene Family
- Molecular Sequence Data
- Membrane Proteins
- Infant, Newborn
- Humans
- Genes
- General Science & Technology
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Kobilka, B. K., Matsui, H., Kobilka, T. S., Yang-Feng, T. L., Francke, U., Caron, M. G., … Regan, J. W. (1987). Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. Science, 238(4827), 650–656. https://doi.org/10.1126/science.2823383
Kobilka, B. K., H. Matsui, T. S. Kobilka, T. L. Yang-Feng, U. Francke, M. G. Caron, R. J. Lefkowitz, and J. W. Regan. “Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor.” Science 238, no. 4827 (October 30, 1987): 650–56. https://doi.org/10.1126/science.2823383.
Kobilka BK, Matsui H, Kobilka TS, Yang-Feng TL, Francke U, Caron MG, et al. Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. Science. 1987 Oct 30;238(4827):650–6.
Kobilka, B. K., et al. “Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor.” Science, vol. 238, no. 4827, Oct. 1987, pp. 650–56. Pubmed, doi:10.1126/science.2823383.
Kobilka BK, Matsui H, Kobilka TS, Yang-Feng TL, Francke U, Caron MG, Lefkowitz RJ, Regan JW. Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. Science. 1987 Oct 30;238(4827):650–656.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
October 30, 1987
Volume
238
Issue
4827
Start / End Page
650 / 656
Location
United States
Related Subject Headings
- Receptors, Adrenergic, alpha
- Phosphoproteins
- Oligodeoxyribonucleotides
- Multigene Family
- Molecular Sequence Data
- Membrane Proteins
- Infant, Newborn
- Humans
- Genes
- General Science & Technology