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cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.

Publication ,  Journal Article
Kobilka, BK; Dixon, RA; Frielle, T; Dohlman, HG; Bolanowski, MA; Sigal, IS; Yang-Feng, TL; Francke, U; Caron, MG; Lefkowitz, RJ
Published in: Proc Natl Acad Sci U S A
January 1987

We have isolated and sequenced a cDNA encoding the human beta 2-adrenergic receptor. The deduced amino acid sequence (413 residues) is that of a protein containing seven clusters of hydrophobic amino acids suggestive of membrane-spanning domains. While the protein is 87% identical overall with the previously cloned hamster beta 2-adrenergic receptor, the most highly conserved regions are the putative transmembrane helices (95% identical) and cytoplasmic loops (93% identical), suggesting that these regions of the molecule harbor important functional domains. Several of the transmembrane helices also share lesser degrees of identity with comparable regions of select members of the opsin family of visual pigments. We have localized the gene for the beta 2-adrenergic receptor to q31-q32 on chromosome 5. This is the same position recently determined for the gene encoding the receptor for platelet-derived growth factor and is adjacent to that for the FMS protooncogene, which encodes the receptor for the macrophage colony-stimulating factor.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

January 1987

Volume

84

Issue

1

Start / End Page

46 / 50

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Protein Conformation
  • Pregnancy
  • Platelet-Derived Growth Factor
  • Placenta
  • Hybrid Cells
  • Humans
  • Female
  • DNA
  • Cricetulus
 

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Kobilka, B. K., Dixon, R. A., Frielle, T., Dohlman, H. G., Bolanowski, M. A., Sigal, I. S., … Lefkowitz, R. J. (1987). cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proc Natl Acad Sci U S A, 84(1), 46–50. https://doi.org/10.1073/pnas.84.1.46
Kobilka, B. K., R. A. Dixon, T. Frielle, H. G. Dohlman, M. A. Bolanowski, I. S. Sigal, T. L. Yang-Feng, U. Francke, M. G. Caron, and R. J. Lefkowitz. “cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.Proc Natl Acad Sci U S A 84, no. 1 (January 1987): 46–50. https://doi.org/10.1073/pnas.84.1.46.
Kobilka BK, Dixon RA, Frielle T, Dohlman HG, Bolanowski MA, Sigal IS, Yang-Feng TL, Francke U, Caron MG, Lefkowitz RJ. cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proc Natl Acad Sci U S A. 1987 Jan;84(1):46–50.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

January 1987

Volume

84

Issue

1

Start / End Page

46 / 50

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Protein Conformation
  • Pregnancy
  • Platelet-Derived Growth Factor
  • Placenta
  • Hybrid Cells
  • Humans
  • Female
  • DNA
  • Cricetulus