Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter.

Journal Article

Disruption of the mouse dopamine transporter gene results in spontaneous hyperlocomotion despite major adaptive changes, such as decreases in neurotransmitter and receptor levels. In homozygote mice, dopamine persists at least 100 times longer in the extracellular space, explaining the biochemical basis of the hyperdopaminergic phenotype and demonstrating the critical role of the transporter in regulating neurotransmission. The dopamine transporter is an obligatory target of cocaine and amphetamine, as these psychostimulants have no effect on locomotor activity or dopamine release and uptake in mice lacking the transporter.

Full Text

Duke Authors

Cited Authors

  • Giros, B; Jaber, M; Jones, SR; Wightman, RM; Caron, MG

Published Date

  • February 15, 1996

Published In

Volume / Issue

  • 379 / 6566

Start / End Page

  • 606 - 612

PubMed ID

  • 8628395

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/379606a0

Language

  • eng

Conference Location

  • England