Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter.
Publication
, Journal Article
Giros, B; Jaber, M; Jones, SR; Wightman, RM; Caron, MG
Published in: Nature
February 15, 1996
Disruption of the mouse dopamine transporter gene results in spontaneous hyperlocomotion despite major adaptive changes, such as decreases in neurotransmitter and receptor levels. In homozygote mice, dopamine persists at least 100 times longer in the extracellular space, explaining the biochemical basis of the hyperdopaminergic phenotype and demonstrating the critical role of the transporter in regulating neurotransmission. The dopamine transporter is an obligatory target of cocaine and amphetamine, as these psychostimulants have no effect on locomotor activity or dopamine release and uptake in mice lacking the transporter.
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Published In
Nature
DOI
ISSN
0028-0836
Publication Date
February 15, 1996
Volume
379
Issue
6566
Start / End Page
606 / 612
Location
England
Related Subject Headings
- Rats
- Protein Precursors
- Nerve Tissue Proteins
- Mice, Knockout
- Mice, Inbred C57BL
- Mice
- Membrane Transport Proteins
- Membrane Glycoproteins
- Male
- Locomotion
Citation
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Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G. (1996). Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature, 379(6566), 606–612. https://doi.org/10.1038/379606a0
Giros, B., M. Jaber, S. R. Jones, R. M. Wightman, and M. G. Caron. “Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter.” Nature 379, no. 6566 (February 15, 1996): 606–12. https://doi.org/10.1038/379606a0.
Giros B, Jaber M, Jones SR, Wightman RM, Caron MG. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature. 1996 Feb 15;379(6566):606–12.
Giros, B., et al. “Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter.” Nature, vol. 379, no. 6566, Feb. 1996, pp. 606–12. Pubmed, doi:10.1038/379606a0.
Giros B, Jaber M, Jones SR, Wightman RM, Caron MG. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature. 1996 Feb 15;379(6566):606–612.
Published In
Nature
DOI
ISSN
0028-0836
Publication Date
February 15, 1996
Volume
379
Issue
6566
Start / End Page
606 / 612
Location
England
Related Subject Headings
- Rats
- Protein Precursors
- Nerve Tissue Proteins
- Mice, Knockout
- Mice, Inbred C57BL
- Mice
- Membrane Transport Proteins
- Membrane Glycoproteins
- Male
- Locomotion