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Catalytic strategies of the hepatitis delta virus ribozymes.

Publication ,  Journal Article
Shih, I-H; Been, MD
Published in: Annu Rev Biochem
2002

The hepatitis delta virus (HDV) ribozymes are self-cleaving RNA sequences critical to the replication of a small RNA genome. A recently determined crystal structure together with biochemical and biophysical studies provides new insight into the possible catalytic mechanism of these ribozymes. The HDV ribozymes are examples of naturally occurring small ribozymes that catalyze cleavage of the RNA backbone with a rate enhancement of 10(6)- to 10(7)-fold over the uncatalyzed rate. To achieve this level of rate enhancement, the HDV ribozymes have been proposed to employ several catalytic strategies that include the use of metal ions, intrinsic binding energy, and a novel example of general acid-base catalysis with a cytosine side chain acting as a proton donor or acceptor.

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Published In

Annu Rev Biochem

DOI

ISSN

0066-4154

Publication Date

2002

Volume

71

Start / End Page

887 / 917

Location

United States

Related Subject Headings

  • Viral Proteins
  • RNA, Viral
  • RNA, Catalytic
  • Protein Folding
  • Protein Binding
  • Nucleic Acid Conformation
  • Molecular Structure
  • Models, Molecular
  • Metals
  • Hepatitis Delta Virus
 

Citation

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Shih, I.-H., & Been, M. D. (2002). Catalytic strategies of the hepatitis delta virus ribozymes. Annu Rev Biochem, 71, 887–917. https://doi.org/10.1146/annurev.biochem.71.110601.135349
Shih, I-hung, and Michael D. Been. “Catalytic strategies of the hepatitis delta virus ribozymes.Annu Rev Biochem 71 (2002): 887–917. https://doi.org/10.1146/annurev.biochem.71.110601.135349.
Shih I-H, Been MD. Catalytic strategies of the hepatitis delta virus ribozymes. Annu Rev Biochem. 2002;71:887–917.
Shih, I-hung, and Michael D. Been. “Catalytic strategies of the hepatitis delta virus ribozymes.Annu Rev Biochem, vol. 71, 2002, pp. 887–917. Pubmed, doi:10.1146/annurev.biochem.71.110601.135349.
Shih I-H, Been MD. Catalytic strategies of the hepatitis delta virus ribozymes. Annu Rev Biochem. 2002;71:887–917.

Published In

Annu Rev Biochem

DOI

ISSN

0066-4154

Publication Date

2002

Volume

71

Start / End Page

887 / 917

Location

United States

Related Subject Headings

  • Viral Proteins
  • RNA, Viral
  • RNA, Catalytic
  • Protein Folding
  • Protein Binding
  • Nucleic Acid Conformation
  • Molecular Structure
  • Models, Molecular
  • Metals
  • Hepatitis Delta Virus