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Marijuana intoxication and brain activation in marijuana smokers.

Publication ,  Journal Article
Mathew, RJ; Wilson, WH; Coleman, RE; Turkington, TG; DeGrado, TR
Published in: Life Sci
1997

OBJECTIVE AND METHOD: The acute effects of delta9 tetrahydrocannabinol (THC) on cerebral blood flow (CBF) were studied in human subjects. Regional CBF was measured with 15O-water and Positron Emission Tomography (PET) in 32 volunteers with a history of exposure to marijuana. Scans were performed before and after intravenous (I.V.) infusion of either of two doses of THC or a placebo, given under double blind conditions. RESULTS: THC but not placebo increased CBF especially in the frontal regions bilaterally, insula and cingulate gyrus and sub-cortical regions with somewhat greater effects in the right hemisphere. While most regions showed significant change at 60 minutes for the lower dose group, the higher dose group had significant change at 30 and 60 minutes. There was a highly significant change in the anterior/posterior ratio for the two THC groups reflecting minimal change in occipital flow but significant increases in frontal flow. Self ratings of THC intoxication showed significant effects, and regression analysis indicated it correlated most markedly with the right frontal region. CONCLUSION: Behavioral manifestations of marijuana intoxication may be associated with increased functional activity of the brain especially the frontal cortex, insula and cingulate gyrus.

Duke Scholars

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

1997

Volume

60

Issue

23

Start / End Page

2075 / 2089

Location

Netherlands

Related Subject Headings

  • Tomography, Emission-Computed
  • Regional Blood Flow
  • Placebos
  • Pharmacology & Pharmacy
  • Marijuana Smoking
  • Male
  • Humans
  • Female
  • Dronabinol
  • Double-Blind Method
 

Citation

APA
Chicago
ICMJE
MLA
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Mathew, R. J., Wilson, W. H., Coleman, R. E., Turkington, T. G., & DeGrado, T. R. (1997). Marijuana intoxication and brain activation in marijuana smokers. Life Sci, 60(23), 2075–2089. https://doi.org/10.1016/s0024-3205(97)00195-1
Mathew, R. J., W. H. Wilson, R. E. Coleman, T. G. Turkington, and T. R. DeGrado. “Marijuana intoxication and brain activation in marijuana smokers.Life Sci 60, no. 23 (1997): 2075–89. https://doi.org/10.1016/s0024-3205(97)00195-1.
Mathew RJ, Wilson WH, Coleman RE, Turkington TG, DeGrado TR. Marijuana intoxication and brain activation in marijuana smokers. Life Sci. 1997;60(23):2075–89.
Mathew, R. J., et al. “Marijuana intoxication and brain activation in marijuana smokers.Life Sci, vol. 60, no. 23, 1997, pp. 2075–89. Pubmed, doi:10.1016/s0024-3205(97)00195-1.
Mathew RJ, Wilson WH, Coleman RE, Turkington TG, DeGrado TR. Marijuana intoxication and brain activation in marijuana smokers. Life Sci. 1997;60(23):2075–2089.
Journal cover image

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

1997

Volume

60

Issue

23

Start / End Page

2075 / 2089

Location

Netherlands

Related Subject Headings

  • Tomography, Emission-Computed
  • Regional Blood Flow
  • Placebos
  • Pharmacology & Pharmacy
  • Marijuana Smoking
  • Male
  • Humans
  • Female
  • Dronabinol
  • Double-Blind Method