Regional cerebral blood flow and depersonalization after tetrahydrocannabinol administration.

Journal Article (Clinical Trial;Journal Article)

OBJECTIVE: The aim of this study was to examine the relationship between depersonalization induced by tetrahydrocannabinol (THC), and regional brain activation. METHOD: Cerebral blood flow (CBF) was measured by means of positron emission tomography (PET) in 59 normal right-handed volunteers before and following intravenous infusions of THC. RESULTS: After THC, CBF showed a global increase which was more marked in the right hemisphere, frontal lobes and anterior cingulate. CONCLUSION: Regression analyses showed positive correlations between the right frontal and anterior cingulate and depersonalization.

Full Text

Duke Authors

Cited Authors

  • Mathew, RJ; Wilson, WH; Chiu, NY; Turkington, TG; Degrado, TR; Coleman, RE

Published Date

  • July 1999

Published In

Volume / Issue

  • 100 / 1

Start / End Page

  • 67 - 75

PubMed ID

  • 10442442

International Standard Serial Number (ISSN)

  • 0001-690X

Digital Object Identifier (DOI)

  • 10.1111/j.1600-0447.1999.tb10916.x


  • eng

Conference Location

  • United States