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APOE genotype and hippocampal volume change in geriatric depression.

Publication ,  Journal Article
Kim, DH; Payne, ME; Levy, RM; MacFall, JR; Steffens, DC
Published in: Biol Psychiatry
March 1, 2002

BACKGROUND: Apolipoprotein E has been associated with hippocampal volume loss in Alzheimer's disease and in elderly controls. In this study, we examined the role of apolipoprotein E and hippocampal volume change in 45 older nondemented depressed subjects. All had baseline and 2-year magnetic resonance imaging scans. METHODS: Hippocampal volumes were determined using a semiautomated method. RESULTS: Compared with 36 depressed subjects without an apolipoprotein E epsilon4 allele, 9 subjects with at least one APOE epsilon4 allele showed significant decline in hippocampal volume, particularly in the right hippocampus. In a logistic model, percent change in right hippocampal volume remained associated with presence of an APOE epsilon4 allele after controlling for age, gender, Mini-Mental State Examination score, and baseline total cerebral volume. CONCLUSIONS: Future studies are needed to explain this association and to determine whether the finding for the right hippocampus has a biological basis, or if it is merely a function of small sample size.

Duke Scholars

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

March 1, 2002

Volume

51

Issue

5

Start / End Page

426 / 429

Location

United States

Related Subject Headings

  • Psychiatry
  • Mental Status Schedule
  • Male
  • Humans
  • Hippocampus
  • Genotype
  • Genetic Carrier Screening
  • Female
  • Depressive Disorder, Major
  • Atrophy
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kim, D. H., Payne, M. E., Levy, R. M., MacFall, J. R., & Steffens, D. C. (2002). APOE genotype and hippocampal volume change in geriatric depression. Biol Psychiatry, 51(5), 426–429. https://doi.org/10.1016/s0006-3223(01)01272-0
Kim, Do Hoon, Martha E. Payne, Robert M. Levy, James R. MacFall, and David C. Steffens. “APOE genotype and hippocampal volume change in geriatric depression.Biol Psychiatry 51, no. 5 (March 1, 2002): 426–29. https://doi.org/10.1016/s0006-3223(01)01272-0.
Kim DH, Payne ME, Levy RM, MacFall JR, Steffens DC. APOE genotype and hippocampal volume change in geriatric depression. Biol Psychiatry. 2002 Mar 1;51(5):426–9.
Kim, Do Hoon, et al. “APOE genotype and hippocampal volume change in geriatric depression.Biol Psychiatry, vol. 51, no. 5, Mar. 2002, pp. 426–29. Pubmed, doi:10.1016/s0006-3223(01)01272-0.
Kim DH, Payne ME, Levy RM, MacFall JR, Steffens DC. APOE genotype and hippocampal volume change in geriatric depression. Biol Psychiatry. 2002 Mar 1;51(5):426–429.
Journal cover image

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

March 1, 2002

Volume

51

Issue

5

Start / End Page

426 / 429

Location

United States

Related Subject Headings

  • Psychiatry
  • Mental Status Schedule
  • Male
  • Humans
  • Hippocampus
  • Genotype
  • Genetic Carrier Screening
  • Female
  • Depressive Disorder, Major
  • Atrophy