APOE genotype and hippocampal volume change in geriatric depression.

Journal Article (Journal Article)

BACKGROUND: Apolipoprotein E has been associated with hippocampal volume loss in Alzheimer's disease and in elderly controls. In this study, we examined the role of apolipoprotein E and hippocampal volume change in 45 older nondemented depressed subjects. All had baseline and 2-year magnetic resonance imaging scans. METHODS: Hippocampal volumes were determined using a semiautomated method. RESULTS: Compared with 36 depressed subjects without an apolipoprotein E epsilon4 allele, 9 subjects with at least one APOE epsilon4 allele showed significant decline in hippocampal volume, particularly in the right hippocampus. In a logistic model, percent change in right hippocampal volume remained associated with presence of an APOE epsilon4 allele after controlling for age, gender, Mini-Mental State Examination score, and baseline total cerebral volume. CONCLUSIONS: Future studies are needed to explain this association and to determine whether the finding for the right hippocampus has a biological basis, or if it is merely a function of small sample size.

Full Text

Duke Authors

Cited Authors

  • Kim, DH; Payne, ME; Levy, RM; MacFall, JR; Steffens, DC

Published Date

  • March 1, 2002

Published In

Volume / Issue

  • 51 / 5

Start / End Page

  • 426 - 429

PubMed ID

  • 11904138

Pubmed Central ID

  • 11904138

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/s0006-3223(01)01272-0


  • eng

Conference Location

  • United States