Age and sex effects on brain morphology.

Journal Article (Clinical Trial;Journal Article)

1. Brain morphology can be assessed readily in vivo using magnetic resonance imaging (MRI). 2. In this study, the effects of age and sex on whole-brain morphology were examined using an operator-controlled computer-segmentation protocol. 3. Results indicated that age was associated with gray-matter volume reduction. 4. Brain-size differences between males and females were primarily attributable to white-matter volume. 5. This study confirms the importance of controlling for age and sex in brain-morphology studies.

Full Text

Duke Authors

Cited Authors

  • Passe, TJ; Rajagopalan, P; Tupler, LA; Byrum, CE; MacFall, JR; Krishnan, KR

Published Date

  • November 1997

Published In

Volume / Issue

  • 21 / 8

Start / End Page

  • 1231 - 1237

PubMed ID

  • 9460088

International Standard Serial Number (ISSN)

  • 0278-5846

Digital Object Identifier (DOI)

  • 10.1016/s0278-5846(97)00160-7


  • eng

Conference Location

  • England