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Human pathologic correlation with PET in ischemic and nonischemic cardiomyopathy.

Publication ,  Journal Article
Berry, JJ; Hoffman, JM; Steenbergen, C; Baker, JA; Floyd, C; Van Trigt, P; Hanson, MW; Coleman, RE
Published in: J Nucl Med
January 1993

To assess the correlation between myocardial perfusion, metabolism and histologic findings in patients with cardiomyopathy, we evaluated myocardial perfusion and metabolism using positron emission tomography (PET) with 13NH3 (ammonia) and 18FDG (fluoro-2-deoxy-glucose) in nine patients prior to undergoing orthotopic cardiac transplantation. Four patients had ischemic cardiomyopathy (ISCM) and five had nonischemic cardiomyopathy (NISCM). Normalized circumferential profile analyses of representative mid-ventricular perfusion and metabolism PET images were performed for each patient. A corresponding mid-ventricular transaxial slice was obtained from the formalin fixed explanted heart and processed for routine histology. Hematoxylin-eosin stained and Masson trichrome stained sections were evaluated and the percentage of the slice occupied by infarct was determined planimetrically at 10-degree intervals in a circumferential manner. A significant correlation was found between circumferential normalized PET count density profile of perfusion and metabolism in both the ischemic and nonischemic groups (ISCM range r = 0.65-0.75; NISCM range, r = 0.70-0.87). Furthermore, there was a correlation in the ISCM group between the extent of matched perfusion/metabolism defects and transmural infarct involvement (r = 0.66-0.88). PET perfusion and metabolic data closely correlate with pathologic infarction in human hearts of ischemic cardiomyopathy patients.

Duke Scholars

Published In

J Nucl Med

ISSN

0161-5505

Publication Date

January 1993

Volume

34

Issue

1

Start / End Page

39 / 47

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Nuclear Medicine & Medical Imaging
  • Myocardium
  • Myocardial Ischemia
  • Middle Aged
  • Male
  • Humans
  • Heart Transplantation
  • Heart
  • Female
 

Citation

APA
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MLA
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Berry, J. J., Hoffman, J. M., Steenbergen, C., Baker, J. A., Floyd, C., Van Trigt, P., … Coleman, R. E. (1993). Human pathologic correlation with PET in ischemic and nonischemic cardiomyopathy. J Nucl Med, 34(1), 39–47.
Berry, J. J., J. M. Hoffman, C. Steenbergen, J. A. Baker, C. Floyd, P. Van Trigt, M. W. Hanson, and R. E. Coleman. “Human pathologic correlation with PET in ischemic and nonischemic cardiomyopathy.J Nucl Med 34, no. 1 (January 1993): 39–47.
Berry JJ, Hoffman JM, Steenbergen C, Baker JA, Floyd C, Van Trigt P, et al. Human pathologic correlation with PET in ischemic and nonischemic cardiomyopathy. J Nucl Med. 1993 Jan;34(1):39–47.
Berry, J. J., et al. “Human pathologic correlation with PET in ischemic and nonischemic cardiomyopathy.J Nucl Med, vol. 34, no. 1, Jan. 1993, pp. 39–47.
Berry JJ, Hoffman JM, Steenbergen C, Baker JA, Floyd C, Van Trigt P, Hanson MW, Coleman RE. Human pathologic correlation with PET in ischemic and nonischemic cardiomyopathy. J Nucl Med. 1993 Jan;34(1):39–47.

Published In

J Nucl Med

ISSN

0161-5505

Publication Date

January 1993

Volume

34

Issue

1

Start / End Page

39 / 47

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Nuclear Medicine & Medical Imaging
  • Myocardium
  • Myocardial Ischemia
  • Middle Aged
  • Male
  • Humans
  • Heart Transplantation
  • Heart
  • Female