Risk factors for postvitrectomy fibrin formation.


Journal Article

We prospectively studied 194 patients undergoing vitrectomy between July 1988 and April 1989 to determine the incidence of postvitrectomy intraocular fibrin formation and the association of a variety of preoperative and intraoperative variables with the formation of severe postvitrectomy fibrin. Overall, 62 (32%) patients developed postvitrectomy fibrin; 25 (13%) had mild fibrin formation, 13 (6.5%) had moderate fibrin formation, and 24 (12.4%) had severe fibrin formation. By logistic multivariate analysis, preoperative factors that were independently predictive of severe fibrin formation included severe flare (P = .004), the presence of a previously placed scleral buckle (P = .001), and poor preoperative visual acuity (P = .007). Anterior epiretinal membrane dissection was the only intraoperative factor that was independently associated with an increased fibrin risk (P = .0003). A risk score derived from the multivariate analysis effectively categorized patients according to their likelihood of developing severe postvitrectomy fibrin. Results of this study may be useful in designing prophylactic interventions to decrease postvitrectomy fibrin formation.

Full Text

Duke Authors

Cited Authors

  • Jaffe, GJ; Schwartz, D; Han, DP; Gottlieb, M; Hartz, A; McCarty, D; Mieler, WF; Abrams, GW

Published Date

  • June 15, 1990

Published In

Volume / Issue

  • 109 / 6

Start / End Page

  • 661 - 667

PubMed ID

  • 2346195

Pubmed Central ID

  • 2346195

International Standard Serial Number (ISSN)

  • 0002-9394

Digital Object Identifier (DOI)

  • 10.1016/s0002-9394(14)72434-1


  • eng

Conference Location

  • United States