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Retinopathy and optic neuropathy in bone marrow transplantation for breast cancer.

Publication ,  Journal Article
Khawly, JA; Rubin, P; Petros, W; Peters, WP; Jaffe, GJ
Published in: Ophthalmology
January 1996

PURPOSE: To characterize the ocular toxicity of a bone marrow transplant regimen does not include total body or focal head irradiation. METHODS: Nine patients with advanced breast cancer were referred for visual symptoms after high-dose chemotherapy with cisplatin, cyclophosphamide, and carmustine and autologous bone marrow transplantation without total body irradiation or local head irradiation. RESULTS: Symptoms consistent with optic neuropathy and retinopathy developed in five patients. Retinopathy alone developed in three patients and optic neuropathy alone developed in one. Retinal abnormalities included cotton-wool spots, intraretinal hemorrhages, and macular exudate. Optic nerve findings included disk swelling and subsequent pallor. Symptoms and signs associated with retinopathy were generally reversible, whereas those associated with optic neuropathy often were permanent. Retinopathy and/or optic neuropathy developed in all of the patients from 1 to 5 months after bone marrow transplantation. Resolution or stabilization of findings was observed 2-4 months after presentation. Two patients with optic neuropathy showed progression of field and acuity loss after 4 months. When compared with control subjects, the exposure of patients to cyclophosphamide and carmustine was no different. However, cisplatin exposure was 1.2-fold higher in patients with ocular toxicity compared with control subjects. CONCLUSION: Optic neuropathy and retinopathy are presumed to arise from the administration of a high-dose chemotherapy regimen. As techniques in supportive care improve, long-term adverse effects of these therapies now are becoming apparent.

Duke Scholars

Published In

Ophthalmology

DOI

ISSN

0161-6420

Publication Date

January 1996

Volume

103

Issue

1

Start / End Page

87 / 95

Location

United States

Related Subject Headings

  • Visual Acuity
  • Transplantation, Autologous
  • Retinal Diseases
  • Optic Nerve Diseases
  • Ophthalmology & Optometry
  • Middle Aged
  • Humans
  • Fundus Oculi
  • Follow-Up Studies
  • Fluorescein Angiography
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Khawly, J. A., Rubin, P., Petros, W., Peters, W. P., & Jaffe, G. J. (1996). Retinopathy and optic neuropathy in bone marrow transplantation for breast cancer. Ophthalmology, 103(1), 87–95. https://doi.org/10.1016/s0161-6420(96)30728-8
Khawly, J. A., P. Rubin, W. Petros, W. P. Peters, and G. J. Jaffe. “Retinopathy and optic neuropathy in bone marrow transplantation for breast cancer.Ophthalmology 103, no. 1 (January 1996): 87–95. https://doi.org/10.1016/s0161-6420(96)30728-8.
Khawly JA, Rubin P, Petros W, Peters WP, Jaffe GJ. Retinopathy and optic neuropathy in bone marrow transplantation for breast cancer. Ophthalmology. 1996 Jan;103(1):87–95.
Khawly, J. A., et al. “Retinopathy and optic neuropathy in bone marrow transplantation for breast cancer.Ophthalmology, vol. 103, no. 1, Jan. 1996, pp. 87–95. Pubmed, doi:10.1016/s0161-6420(96)30728-8.
Khawly JA, Rubin P, Petros W, Peters WP, Jaffe GJ. Retinopathy and optic neuropathy in bone marrow transplantation for breast cancer. Ophthalmology. 1996 Jan;103(1):87–95.
Journal cover image

Published In

Ophthalmology

DOI

ISSN

0161-6420

Publication Date

January 1996

Volume

103

Issue

1

Start / End Page

87 / 95

Location

United States

Related Subject Headings

  • Visual Acuity
  • Transplantation, Autologous
  • Retinal Diseases
  • Optic Nerve Diseases
  • Ophthalmology & Optometry
  • Middle Aged
  • Humans
  • Fundus Oculi
  • Follow-Up Studies
  • Fluorescein Angiography