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Inhibition of human corneal epithelium with immunotoxin 454A12-rRA.

Publication ,  Journal Article
Fulcher, SF; Foulks, GN; Wilkerson, M; Cobo, LM; Jaffe, GJ; Hatchell, DL
Published in: Cornea
September 1992

We examined the effects of the immunotoxin 454A12-rRa on proliferating and confluent human corneal epithelium (HCE) in vitro. Proliferating HCE was sensitive to 454A12-rRA in a dose-dependent fashion. At immunotoxin concentrations of 1,000 ng/ml for 7 days we observed an 86% reduction in cell counts. Confluent HCE was not sensitive to 454A12-rRA at equivalent concentrations of immunotoxin. These data confirm previous observations regarding selective sensitivity of proliferating ocular tissue to immunotoxin, but suggest that HCE is less sensitive to 454A12-rRA than other ocular cell types.

Duke Scholars

Published In

Cornea

DOI

ISSN

0277-3740

Publication Date

September 1992

Volume

11

Issue

5

Start / End Page

413 / 417

Location

United States

Related Subject Headings

  • Ricin
  • Recombinant Fusion Proteins
  • Receptors, Transferrin
  • Ophthalmology & Optometry
  • Mice, Inbred BALB C
  • Mice
  • Immunotoxins
  • Humans
  • Epithelial Cells
  • Dose-Response Relationship, Drug
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fulcher, S. F., Foulks, G. N., Wilkerson, M., Cobo, L. M., Jaffe, G. J., & Hatchell, D. L. (1992). Inhibition of human corneal epithelium with immunotoxin 454A12-rRA. Cornea, 11(5), 413–417. https://doi.org/10.1097/00003226-199209000-00010
Fulcher, S. F., G. N. Foulks, M. Wilkerson, L. M. Cobo, G. J. Jaffe, and D. L. Hatchell. “Inhibition of human corneal epithelium with immunotoxin 454A12-rRA.Cornea 11, no. 5 (September 1992): 413–17. https://doi.org/10.1097/00003226-199209000-00010.
Fulcher SF, Foulks GN, Wilkerson M, Cobo LM, Jaffe GJ, Hatchell DL. Inhibition of human corneal epithelium with immunotoxin 454A12-rRA. Cornea. 1992 Sep;11(5):413–7.
Fulcher, S. F., et al. “Inhibition of human corneal epithelium with immunotoxin 454A12-rRA.Cornea, vol. 11, no. 5, Sept. 1992, pp. 413–17. Pubmed, doi:10.1097/00003226-199209000-00010.
Fulcher SF, Foulks GN, Wilkerson M, Cobo LM, Jaffe GJ, Hatchell DL. Inhibition of human corneal epithelium with immunotoxin 454A12-rRA. Cornea. 1992 Sep;11(5):413–417.

Published In

Cornea

DOI

ISSN

0277-3740

Publication Date

September 1992

Volume

11

Issue

5

Start / End Page

413 / 417

Location

United States

Related Subject Headings

  • Ricin
  • Recombinant Fusion Proteins
  • Receptors, Transferrin
  • Ophthalmology & Optometry
  • Mice, Inbred BALB C
  • Mice
  • Immunotoxins
  • Humans
  • Epithelial Cells
  • Dose-Response Relationship, Drug