Inhibition of human corneal epithelium with immunotoxin 454A12-rRA.

Journal Article (Journal Article)

We examined the effects of the immunotoxin 454A12-rRa on proliferating and confluent human corneal epithelium (HCE) in vitro. Proliferating HCE was sensitive to 454A12-rRA in a dose-dependent fashion. At immunotoxin concentrations of 1,000 ng/ml for 7 days we observed an 86% reduction in cell counts. Confluent HCE was not sensitive to 454A12-rRA at equivalent concentrations of immunotoxin. These data confirm previous observations regarding selective sensitivity of proliferating ocular tissue to immunotoxin, but suggest that HCE is less sensitive to 454A12-rRA than other ocular cell types.

Full Text

Duke Authors

Cited Authors

  • Fulcher, SF; Foulks, GN; Wilkerson, M; Cobo, LM; Jaffe, GJ; Hatchell, DL

Published Date

  • September 1992

Published In

Volume / Issue

  • 11 / 5

Start / End Page

  • 413 - 417

PubMed ID

  • 1424670

International Standard Serial Number (ISSN)

  • 0277-3740

Digital Object Identifier (DOI)

  • 10.1097/00003226-199209000-00010


  • eng

Conference Location

  • United States