Histopathologic features of adult-onset foveomacular pigment epithelial dystrophy.

Journal Article

We studied the clinical and histopathologic characteristics of the eyes obtained after death from a patient with adult-onset foveomacular pigment epithelial dystrophy. The pigmentation seen in the central fovea corresponded histologically to a hyperplastic clump of retinal pigment epithelium. The pale yellow rim surrounding the central pigmentation corresponded histologically to dense periodic acid-Schiff-positive material underlying thinned, atrophic retinal pigment epithelium. Fluorescence microscopy demonstrated homogeneous autofluorescence in the retinal pigment epithelium that was similar in intensity to that of an age-matched control. The results of this clinicopathologic study suggest that in adult-onset foveomacular pigment epithelial dystrophy, an alteration of macular retinal pigment epithelium causes an accumulation of abnormal subretinal pigment epithelial material, photoreceptor degeneration, and serous retinal detachment.

Full Text

Duke Authors

Cited Authors

  • Jaffe, GJ; Schatz, H

Published Date

  • July 1988

Published In

Volume / Issue

  • 106 / 7

Start / End Page

  • 958 - 960

PubMed ID

  • 2455495

International Standard Serial Number (ISSN)

  • 0003-9950

Language

  • eng

Conference Location

  • United States