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Treatment of postvitrectomy fibrin pupillary block with tissue plasminogen activator.

Publication ,  Journal Article
Jaffe, GJ; Lewis, H; Han, DP; Williams, GA; Abrams, GW
Published in: Am J Ophthalmol
August 15, 1989

We injected 25 micrograms of recombinant tissue plasminogen activator into the anterior chamber or the vitreous cavity in seven aphakic patients for pupillary block caused by a complete fibrin pupillary membrane that formed after vitrectomy with fluid-gas exchange. Progressive fibrin deposition resulted in pupillary block by three days after vitrectomy surgery in six patients, and seven days after vitrectomy in one patient. The pupillary block was associated with increased intraocular pressure in six patients. Tissue plasminogen activator was injected via the corneoscleral limbus in five patients and via the pars plana in two patients. In all patients, injection of tissue plasminogen activator resulted in complete fibrinolysis of the fibrin pupillary membrane within four hours, associated with a deepening of the anterior chamber. In the six patients with increased intraocular pressure at the time of tissue plasminogen activator injection, dissolution of the fibrin membrane was associated with a decrease in pressure. In all patients, intraocular pressure had returned to normal by three days after the injection. No complications were associated with the injection.

Duke Scholars

Published In

Am J Ophthalmol

DOI

ISSN

0002-9394

Publication Date

August 15, 1989

Volume

108

Issue

2

Start / End Page

170 / 175

Location

United States

Related Subject Headings

  • Vitreous Hemorrhage
  • Vitreous Body
  • Vitrectomy
  • Tissue Plasminogen Activator
  • Retinal Detachment
  • Recombinant Proteins
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Iris Diseases
 

Citation

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Jaffe, G. J., Lewis, H., Han, D. P., Williams, G. A., & Abrams, G. W. (1989). Treatment of postvitrectomy fibrin pupillary block with tissue plasminogen activator. Am J Ophthalmol, 108(2), 170–175. https://doi.org/10.1016/0002-9394(89)90013-5
Jaffe, G. J., H. Lewis, D. P. Han, G. A. Williams, and G. W. Abrams. “Treatment of postvitrectomy fibrin pupillary block with tissue plasminogen activator.Am J Ophthalmol 108, no. 2 (August 15, 1989): 170–75. https://doi.org/10.1016/0002-9394(89)90013-5.
Jaffe GJ, Lewis H, Han DP, Williams GA, Abrams GW. Treatment of postvitrectomy fibrin pupillary block with tissue plasminogen activator. Am J Ophthalmol. 1989 Aug 15;108(2):170–5.
Jaffe, G. J., et al. “Treatment of postvitrectomy fibrin pupillary block with tissue plasminogen activator.Am J Ophthalmol, vol. 108, no. 2, Aug. 1989, pp. 170–75. Pubmed, doi:10.1016/0002-9394(89)90013-5.
Jaffe GJ, Lewis H, Han DP, Williams GA, Abrams GW. Treatment of postvitrectomy fibrin pupillary block with tissue plasminogen activator. Am J Ophthalmol. 1989 Aug 15;108(2):170–175.
Journal cover image

Published In

Am J Ophthalmol

DOI

ISSN

0002-9394

Publication Date

August 15, 1989

Volume

108

Issue

2

Start / End Page

170 / 175

Location

United States

Related Subject Headings

  • Vitreous Hemorrhage
  • Vitreous Body
  • Vitrectomy
  • Tissue Plasminogen Activator
  • Retinal Detachment
  • Recombinant Proteins
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Iris Diseases