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Impact of genetic polymorphisms on heart failure prognosis.

Publication ,  Journal Article
Le Corvoisier, P; Park, HY; Carlson, KM; Donahue, MP; Marchuk, DA; Rockman, HA
Published in: Arch Mal Coeur Vaiss
March 2003

Recent progress in genomic applications have led to a better understanding of the relationship between genetic background and cardiovascular diseases such as heart failure. The broad variability in heart failure patient outcome is in part secondary to modifier genes, i.e. genes that are not involved in the genesis of a disease but modify the severity of the phenotypic expression once the disease has developed. The strategy most commonly used to identify modifier genes is based on association studies between the severity of the phenotype and the sequence variation(s) of selected candidate gene(s). Using this strategy, several polymorphisms of the beta 1 and beta 2-adrenergic receptors genes and the angiotensin converting enzyme gene have been correlated to the prognosis of patients with heart failure. Recently, we have applied an experimental strategy, known as genome mapping, for the identification of heart failure modifier genes. Genome mapping has previously been used with success to identify the genes involved in the development of both monogenic and multifactorial diseases. We have shown that the prognosis of heart failure mice, induced through calsequestrin overexpression, is linked to two Quantitative Trait Loci localized on chromosomes 2 and 3. Using both strategies (candidate gene and genome mapping) should allow us to identify a number of modifier genes that may provide a more rational approach to identify patients with the worst prognosis and to predict their response to therapy.

Duke Scholars

Published In

Arch Mal Coeur Vaiss

ISSN

0003-9683

Publication Date

March 2003

Volume

96

Issue

3

Start / End Page

197 / 206

Location

France

Related Subject Headings

  • Receptors, Endothelin
  • Receptors, Adrenergic, beta
  • Prognosis
  • Polymorphism, Genetic
  • Peptidyl-Dipeptidase A
  • Models, Animal
  • Mice
  • Humans
  • Heart Failure
  • Cytochrome P-450 CYP11B2
 

Citation

APA
Chicago
ICMJE
MLA
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Le Corvoisier, P., Park, H. Y., Carlson, K. M., Donahue, M. P., Marchuk, D. A., & Rockman, H. A. (2003). Impact of genetic polymorphisms on heart failure prognosis. Arch Mal Coeur Vaiss, 96(3), 197–206.
Le Corvoisier, P., H. Y. Park, K. M. Carlson, M. P. Donahue, D. A. Marchuk, and H. A. Rockman. “Impact of genetic polymorphisms on heart failure prognosis.Arch Mal Coeur Vaiss 96, no. 3 (March 2003): 197–206.
Le Corvoisier P, Park HY, Carlson KM, Donahue MP, Marchuk DA, Rockman HA. Impact of genetic polymorphisms on heart failure prognosis. Arch Mal Coeur Vaiss. 2003 Mar;96(3):197–206.
Le Corvoisier, P., et al. “Impact of genetic polymorphisms on heart failure prognosis.Arch Mal Coeur Vaiss, vol. 96, no. 3, Mar. 2003, pp. 197–206.
Le Corvoisier P, Park HY, Carlson KM, Donahue MP, Marchuk DA, Rockman HA. Impact of genetic polymorphisms on heart failure prognosis. Arch Mal Coeur Vaiss. 2003 Mar;96(3):197–206.
Journal cover image

Published In

Arch Mal Coeur Vaiss

ISSN

0003-9683

Publication Date

March 2003

Volume

96

Issue

3

Start / End Page

197 / 206

Location

France

Related Subject Headings

  • Receptors, Endothelin
  • Receptors, Adrenergic, beta
  • Prognosis
  • Polymorphism, Genetic
  • Peptidyl-Dipeptidase A
  • Models, Animal
  • Mice
  • Humans
  • Heart Failure
  • Cytochrome P-450 CYP11B2