Radiographic quantitation of reversible blood-brain barrier disruption in vivo.
Journal Article
Cranial computed tomography (CT) was used to quantitate disruption of the blood-brain barrier (BBB) in dogs in vivo following intracarotid infusion of hypertonic mannitol. The degree of opening varied with the same dose and infusion rate. The ratio of contrast enhancement in brain vs. venous blood was elevated in 4 of 5 mannitol-treated animals, with the greatest enhancement occurring in the ipsilateral basal ganglia and cortical gray matter. The statistical significance and reproducibility of the derived CT numbers used for brain and venous blood calculations, as well as the linear relationship between iodine concentration and CT enhancement, was affirmed by obtaining multiple consecutive scans.
Full Text
Duke Authors
Cited Authors
- Drayer, BP; Schmeckel, DE; Hedlund, LW; Lischko, MM; Sage, MR; Heinz, ER; Dubois, PJ; Goulding, PL
Published Date
- April 1982
Published In
Volume / Issue
- 143 / 1
Start / End Page
- 85 - 89
PubMed ID
- 6801727
Pubmed Central ID
- 6801727
Electronic International Standard Serial Number (EISSN)
- 1527-1315
International Standard Serial Number (ISSN)
- 0033-8419
Digital Object Identifier (DOI)
- 10.1148/radiology.143.1.6801727
Language
- eng