Work in progress: in vitro analysis of pleural fluid analogs by proton magnetic resonance. Preliminary studies at 1.5T.

Journal Article (Journal Article)

To test the potential of 1.5 Tesla magnetic resonance imaging (MRI) for assessing the protein concentration of pleural effusions, five pleural fluid analogs (saline + 0, 2, 4, 6, 8 g albumin/100 mL) and, for comparison, four saline dilutions of whole blood were evaluated in vitro. The relaxation rates (1/T1, 1/T2) of albumin solutions were determined by 1.5 T spectroscopy (MRS) and correlated with albumin concentration (1/T1:slope 0.02, r + 0.89, P less than .05; 1/T2: slope 0.16, r = 0.997, P less than .001). MRI studies of these solutions showed no significant correlation with 1/T1, but 1/T2 showed a positive correlation with albumin concentration (r = 0.98, P less than .01). Both MRI relaxation rates were significantly correlated with blood concentration, and slopes were greater than for albumin solutions. These preliminary studies, demonstrating differences in correlation between relaxation rates and the concentration of albumin and blood, suggest that MRI has the potential for differentiating pleural effusions of different chemical composition.

Full Text

Duke Authors

Cited Authors

  • Vock, P; Hedlund, LW; Herfkens, RJ; Effmann, EL; Brown, MA; Putman, CE

Published Date

  • May 1987

Published In

Volume / Issue

  • 22 / 5

Start / End Page

  • 382 - 387

PubMed ID

  • 3597006

International Standard Serial Number (ISSN)

  • 0020-9996

Digital Object Identifier (DOI)

  • 10.1097/00004424-198705000-00005


  • eng

Conference Location

  • United States