Prenatal choline supplementation increases NGF levels in the hippocampus and frontal cortex of young and adult rats.

Journal Article (Journal Article)

Female Sprague-Dawley rats received approximately 300 mg/kg per day of choline chloride through their drinking water on days 11 of pregnancy through birth and the level of nerve growth factor (NGF) in the hippocampus and frontal cortex of their male offspring was measured at 20 and 90 days of age. Prenatal choline supplementation caused significant increases in hippocampal NGF levels at 20 and 90 days of age, while levels of NGF in the frontal cortex were elevated in choline-supplemented rats at 20 days of age, but not 90 days of age. These results suggest that increases in NGF levels during development or adulthood may be one mechanism underlying improvements in spatial and temporal memory of adult rats exposed to elevated levels of choline chloride perinatally.

Full Text

Duke Authors

Cited Authors

  • Sandstrom, NJ; Loy, R; Williams, CL

Published Date

  • August 2002

Published In

Volume / Issue

  • 947 / 1

Start / End Page

  • 9 - 16

PubMed ID

  • 12144847

Electronic International Standard Serial Number (EISSN)

  • 1872-6240

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/s0006-8993(02)02900-1


  • eng