Prenatal choline supplementation increases NGF levels in the hippocampus and frontal cortex of young and adult rats.
Female Sprague-Dawley rats received approximately 300 mg/kg per day of choline chloride through their drinking water on days 11 of pregnancy through birth and the level of nerve growth factor (NGF) in the hippocampus and frontal cortex of their male offspring was measured at 20 and 90 days of age. Prenatal choline supplementation caused significant increases in hippocampal NGF levels at 20 and 90 days of age, while levels of NGF in the frontal cortex were elevated in choline-supplemented rats at 20 days of age, but not 90 days of age. These results suggest that increases in NGF levels during development or adulthood may be one mechanism underlying improvements in spatial and temporal memory of adult rats exposed to elevated levels of choline chloride perinatally.
Duke Scholars
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Related Subject Headings
- Rats, Sprague-Dawley
- Rats
- Prenatal Exposure Delayed Effects
- Pregnancy
- Prefrontal Cortex
- Nootropic Agents
- Neurology & Neurosurgery
- Nerve Growth Factor
- Memory
- Male
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Rats, Sprague-Dawley
- Rats
- Prenatal Exposure Delayed Effects
- Pregnancy
- Prefrontal Cortex
- Nootropic Agents
- Neurology & Neurosurgery
- Nerve Growth Factor
- Memory
- Male