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Persistent or recurrent bronchogenic carcinoma: detection with PET and 2-[F-18]-2-deoxy-D-glucose.

Publication ,  Journal Article
Patz, EF; Lowe, VJ; Hoffman, JM; Paine, SS; Harris, LK; Goodman, PC
Published in: Radiology
May 1994

PURPOSE: To assess positron emission tomography (PET) with 2-[fluorine-18]-2-deoxy-D-glucose (FDG) in the differentiation of recurrent bronchogenic carcinoma from fibrosis after therapy. MATERIALS AND METHODS: Any patient treated for bronchogenic carcinoma who had a residual chest radiographic abnormality was eligible. Forty-three patients (mean age, 63.5 years) participated. Chest radiographs and thoracic computed tomographic scans helped localize the abnormality prior to PET. Semiquantitative analysis was performed on FDG PET images with calculated standardized uptake ratios (SURs). Sensitivity, specificity, and confidence intervals for recurrent disease were determined. RESULTS: Thirty-five patients had recurrent or persistent tumor (median SUR, 7.6; range, 1.9-18.7). Eight patients had fibrosis but no evidence of disease (SUR, 1.6; range, 0.6-2.4). The sensitivity for detecting recurrent tumor (SUR > 2.5) was 97.1%, and specificity was 100%. The SUR for recurrent tumor was statistically significantly higher than for fibrosis (P = .0001). CONCLUSION: FDG PET accurately helps differentiate recurrent bronchogenic carcinoma from fibrosis.

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Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

May 1994

Volume

191

Issue

2

Start / End Page

379 / 382

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Sensitivity and Specificity
  • Pulmonary Fibrosis
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Lung
  • Humans
 

Citation

APA
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ICMJE
MLA
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Patz, E. F., Lowe, V. J., Hoffman, J. M., Paine, S. S., Harris, L. K., & Goodman, P. C. (1994). Persistent or recurrent bronchogenic carcinoma: detection with PET and 2-[F-18]-2-deoxy-D-glucose. Radiology, 191(2), 379–382. https://doi.org/10.1148/radiology.191.2.8153309
Patz, E. F., V. J. Lowe, J. M. Hoffman, S. S. Paine, L. K. Harris, and P. C. Goodman. “Persistent or recurrent bronchogenic carcinoma: detection with PET and 2-[F-18]-2-deoxy-D-glucose.Radiology 191, no. 2 (May 1994): 379–82. https://doi.org/10.1148/radiology.191.2.8153309.
Patz EF, Lowe VJ, Hoffman JM, Paine SS, Harris LK, Goodman PC. Persistent or recurrent bronchogenic carcinoma: detection with PET and 2-[F-18]-2-deoxy-D-glucose. Radiology. 1994 May;191(2):379–82.
Patz, E. F., et al. “Persistent or recurrent bronchogenic carcinoma: detection with PET and 2-[F-18]-2-deoxy-D-glucose.Radiology, vol. 191, no. 2, May 1994, pp. 379–82. Pubmed, doi:10.1148/radiology.191.2.8153309.
Patz EF, Lowe VJ, Hoffman JM, Paine SS, Harris LK, Goodman PC. Persistent or recurrent bronchogenic carcinoma: detection with PET and 2-[F-18]-2-deoxy-D-glucose. Radiology. 1994 May;191(2):379–382.
Journal cover image

Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

May 1994

Volume

191

Issue

2

Start / End Page

379 / 382

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Sensitivity and Specificity
  • Pulmonary Fibrosis
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Lung
  • Humans