Differential glycemic effects of morphine in diabetic and normal mice.


Journal Article

C57BL/6J ob/ob mice, C57BL/6J+/? lean mice and A/J mice were given injections of 10 mg/kg of morphine or an equal volume of saline, and then blood was sampled by retroorbital sinus puncture. In addition, animals from each strain were exposed to a brief experimental stress ten minutes after the administration of morphine or saline. While morphine produced significant increases in serum glucose in albino mice, morphine lowered blood insulin in both C57BL/6J ob/ob and C57BL/6J+/? mice. Morphine significantly lowered blood insulin in A/J mice, but effects in C57BL/6J mice were not significant. In contrast, morphine attenuated blood glucose and insulin during stress in C57BL/6J ob/ob but did not significantly affect either glucose or insulin during stress in lean C57BL/6J or A/J mice. These results are interpreted in the light of other data suggesting that endogenous opiates modulate the effects of sympathetic nervous system activity in type II diabetes.

Full Text

Duke Authors

Cited Authors

  • Surwit, RS; McCubbin, JA; Kuhn, CM; Cochrane, C; Feinglos, MN

Published Date

  • March 1989

Published In

Volume / Issue

  • 38 / 3

Start / End Page

  • 282 - 285

PubMed ID

  • 2645504

Pubmed Central ID

  • 2645504

International Standard Serial Number (ISSN)

  • 0026-0495

Digital Object Identifier (DOI)

  • 10.1016/0026-0495(89)90089-9


  • eng

Conference Location

  • United States