The role of motor activity in diet-induced obesity in C57BL/6J mice.

Journal Article (Journal Article)

Previous research in our laboratory has demonstrated that the C57BL/6J (B/6J) mouse has a predisposition to develop severe obesity if placed on a high-fat diet. In the present study we assessed the role of physical activity in this phenomenon. Obesity-prone B/6J and obesity-resistant A/J mice were placed on one of four diets; high fat/high sucrose, high fat/low sucrose, low fat/high sucrose, and low fat/low sucrose. After 4 months, all animals on the high-fat diets had gained more weight than animals on the low-fat diets, and this phenomenon was greatly exaggerated in B/6J mice. Despite the fact that B/6J mice gained more weight than A/J mice on high-fat diets without consuming more calories, spontaneous motor activity was elevated in B/6J mice compared to A/J mice. There was no effect of the diets on activity either within or across strains. These data suggest that predisposition to diet-induced obesity is not explainable by reduced levels of physical activity.

Full Text

Duke Authors

Cited Authors

  • Brownlow, BS; Petro, A; Feinglos, MN; Surwit, RS

Published Date

  • July 1996

Published In

Volume / Issue

  • 60 / 1

Start / End Page

  • 37 - 41

PubMed ID

  • 8804640

International Standard Serial Number (ISSN)

  • 0031-9384

Digital Object Identifier (DOI)

  • 10.1016/0031-9384(95)02210-4


  • eng

Conference Location

  • United States