Endogenous opiate peptides, stress reactivity, and risk for hypertension.
Published
Journal Article
Endogenous opiate peptides can regulate neuroendocrine and circulatory responses to behavioral stress and may be important in the pathogenic effects of sympathoadrenal reactivity. We tested this hypothesis by examining the effect of the opiate antagonist naloxone on blood pressure responses to behavioral stress in young adults with high, medium, or low casual blood pressures. Naloxone increased mean arterial pressure responses to stress in subjects with low casual pressure, but had no significant effect on responses in subjects with high casual pressure. These results suggest opioidergic inhibition of sympathetic nervous system responses may be deficient in persons at risk for essential hypertension.
Full Text
Duke Authors
Cited Authors
- McCubbin, JA; Surwit, RS; Williams, RB
Published Date
- September 1985
Published In
Volume / Issue
- 7 / 5
Start / End Page
- 808 - 811
PubMed ID
- 4030048
Pubmed Central ID
- 4030048
International Standard Serial Number (ISSN)
- 0194-911X
Digital Object Identifier (DOI)
- 10.1161/01.hyp.7.5.808
Language
- eng
Conference Location
- United States