Intra-arterial reserpine for Raynaud's syndrome. Systemic reactions without therapeutic benefit.
(Clinical Trial;Journal Article)
Twenty-four patients classified as having Raynaud's disease or Raynaud's phenomenon were given bilateral brachial artery injections of reserpine or saline in a double-blind fashion. In the six weeks following injection, there was no indication that reserpine produced clinical improvement or changed vasomotor reactivity in the treated patients. However, intra-arterial reserpine did produce systemic cardiovascular effects lasting up to six weeks. It is concluded that intra-arterial reserpine as used in this study is an ineffective treatment for Raynaud's disease or Raynaud's phenomenon and may have significant adverse effects.
Surwit, RS; Gilgor, RS; Duvic, M; Allen, LM; Neal, JA
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