Intra-arterial reserpine for Raynaud's syndrome. Systemic reactions without therapeutic benefit.
Journal Article (Clinical Trial;Journal Article)
Twenty-four patients classified as having Raynaud's disease or Raynaud's phenomenon were given bilateral brachial artery injections of reserpine or saline in a double-blind fashion. In the six weeks following injection, there was no indication that reserpine produced clinical improvement or changed vasomotor reactivity in the treated patients. However, intra-arterial reserpine did produce systemic cardiovascular effects lasting up to six weeks. It is concluded that intra-arterial reserpine as used in this study is an ineffective treatment for Raynaud's disease or Raynaud's phenomenon and may have significant adverse effects.
Full Text
Duke Authors
Cited Authors
- Surwit, RS; Gilgor, RS; Duvic, M; Allen, LM; Neal, JA
Published Date
- September 1, 1983
Published In
Volume / Issue
- 119 / 9
Start / End Page
- 733 - 735
PubMed ID
- 6614959
International Standard Serial Number (ISSN)
- 0003-987X
Language
- eng
Conference Location
- United States