Intra-arterial reserpine for Raynaud's syndrome. Systemic reactions without therapeutic benefit.

Journal Article (Clinical Trial;Journal Article)

Twenty-four patients classified as having Raynaud's disease or Raynaud's phenomenon were given bilateral brachial artery injections of reserpine or saline in a double-blind fashion. In the six weeks following injection, there was no indication that reserpine produced clinical improvement or changed vasomotor reactivity in the treated patients. However, intra-arterial reserpine did produce systemic cardiovascular effects lasting up to six weeks. It is concluded that intra-arterial reserpine as used in this study is an ineffective treatment for Raynaud's disease or Raynaud's phenomenon and may have significant adverse effects.

Full Text

Duke Authors

Cited Authors

  • Surwit, RS; Gilgor, RS; Duvic, M; Allen, LM; Neal, JA

Published Date

  • September 1, 1983

Published In

Volume / Issue

  • 119 / 9

Start / End Page

  • 733 - 735

PubMed ID

  • 6614959

International Standard Serial Number (ISSN)

  • 0003-987X


  • eng

Conference Location

  • United States